Mutations at homologous positions to ABCB11 p.Val43
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB11 |
p.Val43Ile
p.Ser701Pro
|
N
N
N
N
?
|
| ABCB1 |
p.Pro32Asp
p.Ser658Arg
|
N
N
?
N
N
?
|
| ABCB2 |
p.Gly183Asp
|
N
N
?
|
| ABCB4 |
p.Trp658*
|
-
-
?
|
Mutations +/- 5 a.a. around the position:
| ABCB11 |
p.Arg696Gln
p.Arg696Trp
p.Arg698His
p.Arg698Cys
p.Ser699Pro
p.Gln702*
|
N
N
?
D
D
?
D
D
N
D
D
?
N
D
?
-
-
?
|
| ABCB1 |
p.Val34Ala
p.Ser35Ala
p.Ser35Ile
p.Phe37Ala
p.Arg659Gln
p.Ser660Ala
p.Ser660Glu
p.Ser661Glu
p.Ser661Ala
p.Leu662Arg
|
D
D
?
D
N
?
D
D
?
D
N
?
N
N
?
N
N
?
N
N
?
N
N
?
N
N
?
N
N
?
|
| ABCB4 |
p.Thr34Met
|
N
N
|
| ABCB9 |
p.Val121Met
|
D
N
?
|
The alignment around the queried position:
ABCB11 12
K
F
G
E
E
N
D
F
E
S
D
K
S
Y
N
N
D
K
K
S
-
-
-
-
-
-
-
-
R
L
Q
D
E
K
K
G
D
G
R
V
G
F
F
Q
F
R
F
S
S
T
D
I
W
L
F
V
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
66
ABCB1 7
R
N
G
A
K
K
-
-
-
-
K
N
F
K
L
N
K
-
-
-
-
-
-
-
-
E
K
K
E
K
K
-
-
T
V
S
M
F
R
L
D
L
Y
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
55
ABCB1 641
A
D
E
K
S
E
-
-
-
-
-
-
-
I
D
A
L
E
M
S
-
-
-
-
-
-
-
-
S
N
D
-
-
-
-
-
-
-
I
R
R
V
G
Q
Q
D
R
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681
ABCB2 152
W
L
A
A
K
P
L
A
A
L
G
L
A
L
P
G
L
A
L
-
-
-
-
-
-
-
-
F
R
E
L
I
S
W
G
A
P
S
A
D
S
T
R
L
L
H
W
G
S
H
P
T
A
V
V
S
Y
A
A
L
P
A
A
A
L
-
-
-
-
-
-
-
-
-
-
214
ABCB3 58
L
L
G
F
V
G
T
L
L
L
P
L
L
A
T
P
T
V
S
-
-
-
-
-
-
-
-
L
R
A
L
V
A
G
A
S
R
A
P
P
A
R
V
A
S
A
P
W
S
-
-
-
-
W
L
L
V
G
Y
G
A
A
G
L
S
W
S
L
-
-
-
-
-
-
-
-
-
-
116
ABCB4 7
K
N
G
T
A
W
R
P
T
S
A
E
D
F
E
L
G
I
S
S
-
-
-
-
-
-
-
-
K
Q
K
R
K
K
K
T
V
K
M
I
G
V
L
T
L
F
Y
S
D
W
Q
D
K
L
F
M
S
L
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
61
ABCB4 641
E
F
E
L
N
D
E
-
-
-
-
-
-
-
K
A
A
T
M
A
-
-
-
-
-
-
-
-
P
N
G
-
-
-
-
-
-
-
K
S
R
L
F
R
-
H
S
Q
N
L
K
N
S
Q
M
C
Q
K
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680
ABCB5 107
T
S
A
L
D
S
E
S
S
-
-
A
V
Q
A
A
L
E
K
A
-
-
-
-
-
-
-
-
S
K
G
R
T
T
I
V
V
A
H
R
L
S
T
I
R
S
A
D
L
I
V
T
L
K
D
G
M
L
A
E
K
G
A
H
A
E
L
M
A
K
R
G
L
Y
Y
S
L
V
M
176
ABCB6 98
A
R
G
A
P
L
P
S
Y
L
L
L
A
S
V
L
E
S
L
A
G
A
G
L
W
L
L
V
V
E
R
S
Q
A
R
Q
R
L
A
M
G
I
W
I
K
F
R
H
S
P
G
L
L
L
L
W
T
V
A
F
A
A
E
N
L
A
L
V
S
W
N
P
Q
W
W
W
A
R
177
ABCB7 52
A
R
A
Y
Q
I
P
-
-
-
-
-
-
-
-
-
E
S
L
K
-
-
-
-
-
-
-
-
-
-
-
-
S
I
T
W
Q
R
L
G
K
G
N
S
G
Q
F
L
D
A
A
K
A
L
Q
V
W
P
L
I
E
K
R
T
-
-
-
-
-
C
W
H
G
-
-
-
-
-
-
-
99
ABCB8 54
Y
R
S
S
S
L
L
R
A
V
A
H
L
R
S
Q
L
W
A
H
L
-
-
-
-
-
-
-
-
P
R
A
P
L
A
P
R
W
S
P
S
A
W
C
W
V
G
G
A
L
L
G
-
-
-
P
M
V
L
S
K
H
P
H
L
C
L
V
A
L
-
-
-
-
-
-
-
-
-
-
113
ABCB9 95
I
Y
A
M
V
K
L
L
L
F
S
E
V
R
R
P
I
R
D
P
W
-
-
-
-
-
-
-
-
F
W
A
L
F
W
T
Y
I
S
L
G
A
S
F
L
L
W
W
L
S
-
-
-
-
T
V
R
P
G
T
Q
A
L
E
P
G
A
A
-
-
-
-
-
-
-
-
-
-
153
ABCB10 76
G
P
G
A
R
G
V
L
G
L
A
R
L
L
G
L
W
A
R
G
-
-
-
-
-
-
-
-
P
G
S
C
R
C
G
A
F
A
G
P
G
A
P
R
L
P
R
A
R
F
P
-
-
-
G
G
P
A
A
A
A
W
A
G
D
E
A
W
R
-
-
-
-
-
-
-
-
-
-
135
ABCB11 670
K
D
A
T
E
D
L
A
R
T
F
S
R
G
S
Y
Q
D
S
-
-
-
-
-
-
-
-
L
R
A
S
I
Q
K
L
S
Y
L
V
H
P
P
L
A
V
V
D
H
K
S
T
Y
E
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724