Mutations at homologous positions to ABCB4 p.Ala250
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB4 |
p.Ala250Pro
p.Ala250Leu
|
D
D
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCB4 |
p.Ala254Leu
p.Glu888*
|
D
D
?
-
-
?
|
| ABCB1 |
p.Glu243Ala
p.Ala250Pro
p.Gly251Val
p.Val253Ser
p.Ser893Ala
p.Ser893Thr
p.Gly894Thr
|
D
D
?
D
D
?
D
D
?
D
D
?
N
N
N
D
N
N
D
D
?
|
| ABCB11 |
p.Ala277Glu
p.Lys930*
p.Gln931Pro
p.Ile939Met
|
D
D
?
-
-
?
D
D
?
N
D
?
|
| ABCB3 |
p.Val331Cys
|
N
D
?
|
The alignment around the queried position:
ABCB4 212
R
G
-
W
K
L
L
V
I
M
A
I
P
I
L
G
L
S
A
A
V
W
A
K
I
L
S
A
F
S
K
E
L
A
A
Y
K
A
G
V
A
E
E
A
L
G
A
I
R
T
V
I
A
F
G
G
Q
N
K
E
L
E
R
Q
K
H
L
E
N
K
E
I
G
290
ABCB1 210
-
K
L
T
L
V
I
L
I
V
L
V
S
F
T
D
K
L
L
A
Y
A
K
A
A
V
Q
L
N
K
L
E
E
A
R
I
288
ABCB1 853
-
Q
L
T
L
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
K
I
A
T
E
A
I
E
N
T
V
L
T
Q
E
Q
K
F
E
H
M
Y
A
Q
S
L
Q
V
P
Y
R
N
S
931
ABCB2 383
G
S
-
V
S
L
T
M
V
T
L
T
L
P
L
L
F
L
L
P
K
K
G
K
W
Q
L
L
E
V
Q
V
R
E
S
L
A
K
S
S
Q
V
A
I
E
A
L
S
A
M
P
T
V
R
S
F
A
N
E
E
G
E
A
Q
K
F
R
E
K
L
Q
E
I
K
T
L
N
461
ABCB3 288
I
S
-
P
R
L
L
L
S
L
L
H
M
P
F
T
I
A
A
E
K
V
Y
N
T
H
Q
E
V
L
R
E
I
Q
D
A
V
A
R
A
G
Q
V
R
E
A
V
G
L
Q
T
V
R
S
F
G
A
E
E
H
E
V
R
Y
K
E
A
L
E
Q
R
Q
L
Y
366
ABCB4 852
Y
G
-
W
Q
L
T
L
L
L
A
V
V
P
I
I
A
V
S
G
I
V
E
M
K
L
L
A
G
N
A
K
R
D
K
K
L
E
A
A
G
K
I
A
T
E
A
I
E
N
I
R
T
V
V
L
T
Q
E
R
K
F
E
S
M
Y
V
E
K
L
Y
G
P
Y
R
N
S
930
ABCB5 388
Y
G
-
W
E
M
T
F
L
I
L
S
I
A
P
V
L
A
V
T
G
M
I
E
T
A
A
M
T
G
F
A
N
K
D
K
Q
E
L
K
H
A
G
K
I
A
T
E
A
L
E
N
I
R
T
I
V
S
L
T
R
E
K
A
F
E
Q
M
Y
E
E
M
L
Q
T
Q
H
R
N
T
466
ABCB6 408
F
F
N
A
W
F
G
L
I
V
F
L
C
M
S
L
L
T
L
T
I
V
V
T
E
W
R
T
K
F
R
R
A
M
N
T
Q
E
N
A
T
R
A
R
V
D
S
L
L
N
F
E
T
V
K
Y
Y
N
A
E
S
Y
E
V
E
R
Y
R
E
A
I
I
K
Y
Q
G
L
E
487
ABCB7 288
K
C
G
A
Q
F
L
V
T
L
G
T
L
G
T
Y
T
A
F
T
V
A
V
T
R
W
R
T
R
F
R
I
E
M
N
K
A
D
N
D
A
G
N
A
A
I
D
S
L
L
N
Y
E
T
V
K
Y
F
N
N
E
R
Y
E
A
Q
R
Y
D
G
F
L
K
T
Y
E
T
A
S
367
ABCB8 290
L
S
-
T
R
L
T
L
L
L
M
V
A
T
P
A
L
M
G
V
G
T
L
M
G
S
G
L
R
K
L
S
R
Q
C
Q
E
Q
I
A
R
A
M
G
V
A
D
E
A
L
G
N
V
R
T
V
R
A
F
A
M
E
Q
R
E
E
E
R
Y
G
A
E
L
E
A
C
R
C
R
A
368
ABCB9 324
L
S
-
W
Q
L
S
L
V
T
F
M
G
F
P
I
I
M
M
V
S
N
I
Y
G
K
Y
Y
K
R
L
S
K
E
V
Q
N
A
L
A
R
A
S
N
T
A
E
E
T
I
S
A
M
K
T
V
R
S
F
A
N
E
E
E
E
A
E
V
Y
L
R
K
L
Q
Q
V
Y
K
L
N
402
ABCB10 310
V
S
-
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
388
ABCB11 237
R
-
W
K
L
L
V
I
I
S
V
S
P
L
I
G
I
G
A
T
I
L
S
V
S
K
F
T
D
Y
E
L
K
A
Y
A
K
G
V
V
A
D
I
S
S
M
R
T
A
A
F
G
K
E
V
E
Y
E
K
N
L
V
F
A
W
G
315
ABCB11 896
F
S
-
W
K
L
L
V
I
L
C
F
F
P
F
L
A
L
S
G
A
T
Q
T
R
M
L
G
F
S
D
A
L
E
M
V
G
Q
T
N
E
A
L
S
N
I
T
V
A
G
I
G
K
E
R
F
I
E
A
L
E
E
L
E
K
P
F
K
T
A
974