Mutations at homologous positions to ABCC8 p.Ser120
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCC8 |
p.Ser120Ala
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
ABCC8 |
p.Ala116Pro
p.Val118Ile
p.Val118Cys
p.His125Gln
|
N
D
?
N
N
?
N
N
?
D
D
?
|
ABCC7 |
p.Met1Val
p.Arg3Trp
p.Pro5Leu
|
N
N
D
D
D
?
D
D
D
|
The alignment around the queried position:
ABCC8 84
L
C
E
L
S
G
V
S
H
H
L
L
Y
M
P
-
-
-
A
M
F
M
A
T
V
V
Y
Y
N
I
T
S
N
P
K
I
A
L
L
V
Y
L
F
I
T
K
T
K
F
V
K
F
L
D
160
ABCC1 84
V
A
L
F
Y
E
R
R
G
I
F
A
F
L
S
-
-
-
T
L
L
G
I
T
M
L
L
A
T
F
L
I
Q
L
E
R
R
K
G
V
Q
-
S
S
G
I
M
L
F
L
V
A
L
V
L
A
L
R
S
K
I
M
T
159
ABCC2 78
L
A
I
E
L
A
L
V
L
T
E
D
S
-
G
Q
A
T
V
P
A
V
Y
T
-
-
-
N
P
S
L
Y
L
G
T
W
L
L
V
L
L
I
Q
Y
S
W
C
V
Q
K
N
S
W
F
L
S
L
F
W
I
L
S
I
L
C
G
T
F
Q
F
Q
T
-
L
I
R
152
ABCC3 83
V
S
W
A
D
L
F
Y
S
F
H
G
L
V
H
G
A
P
A
P
F
F
V
T
-
-
-
P
L
V
V
G
V
T
M
L
L
A
T
L
L
I
Q
Y
E
R
L
Q
G
V
Q
-
S
S
G
V
L
I
I
F
W
F
L
C
V
V
C
A
I
V
P
F
R
S
K
I
L
L
158
ABCC4 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
L
P
V
Y
Q
E
V
K
P
N
P
L
Q
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
ABCC5 31
R
D
R
E
D
S
K
F
R
R
T
R
L
E
C
Q
D
A
L
E
T
A
A
R
A
-
-
-
-
-
-
-
-
-
-
-
-
-
E
G
L
S
L
D
A
S
M
H
S
Q
L
R
I
L
D
E
E
H
P
K
G
K
Y
H
H
G
L
S
A
L
K
P
I
R
T
T
S
K
H
97
ABCC6 82
L
C
T
S
S
V
A
V
A
L
W
K
I
Q
Q
G
T
P
E
A
P
E
F
L
I
H
-
-
-
P
T
V
W
L
T
T
M
S
F
A
V
F
L
I
H
T
R
K
K
V
Q
-
S
S
G
V
L
F
G
Y
W
L
L
C
F
V
L
P
A
T
N
A
A
Q
-
-
-
154
ABCC7 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Q
S
L
E
K
A
S
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
ABCC9 82
V
H
V
C
E
I
A
E
G
I
V
S
D
S
R
R
E
S
R
H
L
H
L
F
M
P
-
-
-
A
V
M
G
F
V
A
T
T
T
S
I
V
Y
Y
H
N
I
E
T
S
N
F
P
K
L
L
L
A
L
F
L
Y
W
V
M
A
F
T
K
T
I
K
L
V
K
Y
C
Q
S
158
ABCC10 79
F
P
L
L
D
L
L
P
V
A
L
P
P
G
A
G
P
G
P
I
G
L
E
V
L
A
G
C
V
A
A
V
A
W
I
S
H
S
L
A
L
W
V
L
A
H
S
P
H
H
S
R
G
P
L
A
L
L
V
A
L
L
P
A
P
A
L
V
L
T
V
L
W
H
C
Q
R
G
158
ABCC11 25
-
-
-
-
-
-
-
-
-
-
-
D
D
M
V
S
G
L
I
Y
K
T
Y
T
L
Q
-
-
-
-
-
-
-
-
-
-
-
-
-
D
G
P
W
S
Q
Q
E
R
N
P
E
A
P
G
R
A
A
V
P
P
W
G
K
Y
D
A
A
L
R
T
M
I
P
F
R
P
K
P
R
F
80
ABCC12 1
-
-
-
-
-
-
-
-
-
-
-
-
-
M
V
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
G
P
Y
L
I
S
D
L
D
Q
R
G
R
R
R
S
F
A
-
-
-
E
R
Y
D
P
S
L
K
T
M
I
P
V
R
P
C
A
R
L
41