Mutations at homologous positions to ABCB11 p.Gly19
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB11 |
p.Gly19Arg
p.Met677Val
p.Met677Leu
|
N
N
?
N
N
?
D
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB11 |
p.Asp676Tyr
|
N
N
?
|
| ABCB1 |
p.Gly10Arg
p.Phe17Leu
p.Ser644Arg
|
N
N
?
N
N
?
N
N
?
|
| ABCB10 |
p.Ser80Cys
|
N
N
?
|
| ABCB2 |
p.Leu156Tyr
p.Ala160Cys
|
N
N
?
N
N
?
|
| ABCB3 |
p.Cys70Ser
|
N
D
?
|
| ABCB4 |
p.Gly19Arg
p.Arg652Gly
|
N
N
?
D
N
?
|
| ABCB5 |
p.Val115Glu
|
N
N
?
|
The alignment around the queried position:
ABCB11 1
-
-
-
M
S
D
S
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
V
I
L
R
S
I
K
K
F
G
E
E
N
D
F
E
S
D
K
S
Y
N
N
D
K
K
S
-
-
-
-
-
-
-
-
R
L
Q
D
E
K
K
G
D
G
R
V
G
F
F
Q
F
51
ABCB1 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
D
L
E
G
D
R
N
G
A
K
K
-
-
-
-
K
N
F
K
L
N
K
-
-
-
-
-
-
-
-
E
K
K
E
K
K
-
-
T
V
S
M
F
40
ABCB1 629
-
-
-
-
Q
T
G
N
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
V
E
L
N
A
A
D
E
K
S
E
-
-
-
-
-
-
-
I
D
A
L
E
M
S
-
-
-
-
-
-
-
-
S
N
D
-
-
-
-
-
-
-
I
R
666
ABCB2 120
V
G
L
S
R
W
A
V
L
W
L
G
A
C
G
L
R
A
T
V
G
K
S
E
N
A
G
A
Q
G
W
L
A
A
K
P
L
A
A
L
G
L
A
L
P
G
L
A
L
-
-
-
-
-
-
-
-
F
R
E
L
I
S
W
G
A
P
S
A
D
S
T
R
L
L
191
ABCB3 41
E
G
T
L
R
G
G
L
W
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
L
L
K
L
R
G
L
L
G
F
V
G
T
L
L
L
P
L
L
A
T
P
T
V
S
-
-
-
-
-
-
-
-
L
R
A
L
V
A
G
A
S
R
A
P
P
A
R
V
A
S
A
97
ABCB4 1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
D
L
E
A
A
K
N
G
T
A
W
R
P
T
S
A
E
D
F
E
L
G
I
S
S
-
-
-
-
-
-
-
-
K
Q
K
R
K
K
K
T
V
K
M
I
G
V
L
T
L
F
46
ABCB4 631
-
-
-
-
Q
T
S
S
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
S
E
-
-
E
F
E
L
N
D
E
-
-
-
-
-
-
-
K
A
A
T
M
A
-
-
-
-
-
-
-
-
P
N
G
-
-
-
-
-
-
-
K
S
R
L
F
R
-
H
665
ABCB5 75
E
K
G
A
Q
M
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
I
L
D
E
A
T
S
A
L
D
S
E
S
S
-
-
A
V
Q
A
A
L
E
K
A
-
-
-
-
-
-
-
-
S
K
G
R
T
T
I
V
V
A
H
R
L
S
T
I
R
S
A
144
ABCB6 66
A
G
P
R
I
S
Y
V
L
Q
L
L
L
A
T
L
Q
A
A
L
P
L
A
G
L
A
G
R
V
G
T
A
R
G
A
P
L
P
S
Y
L
L
L
A
S
V
L
E
S
L
A
G
A
G
L
W
L
L
V
V
E
R
S
Q
A
R
Q
R
L
A
M
G
I
W
I
K
F
R
145
ABCB7 37
S
G
P
Q
W
R
P
H
Q
L
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
A
L
G
T
A
R
A
Y
Q
I
P
-
-
-
-
-
-
-
-
-
E
S
L
K
-
-
-
-
-
-
-
-
-
-
-
-
S
I
T
W
Q
R
L
G
K
G
N
S
G
Q
F
L
78
ABCB8 37
N
G
K
T
G
Q
L
H
K
A
E
G
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
Y
S
D
G
Y
R
S
S
S
L
L
R
A
V
A
H
L
R
S
Q
L
W
A
H
L
-
-
-
-
-
-
-
-
P
R
A
P
L
A
P
R
W
S
P
S
A
W
C
W
V
G
G
93
ABCB9 74
L
G
P
R
R
L
R
A
S
W
L
V
I
T
-
-
-
-
-
-
-
-
-
-
-
L
V
C
L
F
V
G
I
Y
A
M
V
K
L
L
L
F
S
E
V
R
R
P
I
R
D
P
W
-
-
-
-
-
-
-
-
F
W
A
L
F
W
T
Y
I
S
L
G
A
S
F
L
L
W
134
ABCB10 54
A
G
P
A
L
L
W
G
V
G
A
A
R
R
-
-
-
-
-
-
-
-
-
-
W
R
S
G
C
R
G
G
G
P
G
A
R
G
V
L
G
L
A
R
L
L
G
L
W
A
R
G
-
-
-
-
-
-
-
-
P
G
S
C
R
C
G
A
F
A
G
P
G
A
P
R
L
P
R
115
ABCB11 657
-
-
-
-
Q
S
Q
G
N
Q
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
L
N
E
E
D
I
K
D
A
T
E
D
L
A
R
T
F
S
R
G
S
Y
Q
D
S
-
-
-
-
-
-
-
-
L
R
A
S
I
Q
K
L
S
Y
L
V
H
709