Mutations at homologous positions to ABCB11 p.Ser194

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

Mutations +/- 5 a.a. around the position:

The alignment around the queried position:

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 465
ABCB11 160
I
C
-
-
-
F
W
V
I
A
A
A
R
Q
I
Q
K
M
R
K
F
Y
F
R
R
I
M
R
M
E
I
G
W
F
D
-
-
C
N
S
V
G
E
L
N
T
R
F
S
D
D
I
N
K
I
N
D
A
I
A
D
Q
M
A
L
F
I
Q
R
M
T
S
T
I
C
G
F
L
L
G
 234
ABCB1 133
V
S
-
-
-
F
W
C
L
A
A
G
R
Q
I
H
K
I
R
K
Q
F
F
H
A
I
M
R
Q
E
I
G
W
F
D
-
-
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
S
M
A
T
F
F
T
G
F
I
V
G
 207
ABCB1 774
G
F
-
-
-
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
R
S
M
L
R
Q
D
V
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D
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K
N
T
T
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A
L
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L
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A
A
Q
V
K
G
A
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G
S
R
L
A
V
I
T
Q
N
I
A
N
L
G
T
G
I
I
I
S
 850
ABCB2 306
D
G
-
-
-
I
Y
N
N
T
M
G
H
V
H
S
H
L
Q
G
E
V
F
G
A
V
L
R
Q
E
T
E
F
F
Q
-
-
Q
N
Q
T
G
N
I
M
S
R
V
T
E
D
T
S
T
L
S
D
S
L
S
E
N
L
S
L
F
L
W
Y
L
V
R
G
L
C
L
L
G
I
M
 380
ABCB3 211
G
G
-
-
-
C
F
T
Y
T
M
S
R
I
N
L
R
I
R
E
Q
L
F
S
S
L
L
R
Q
D
L
G
F
F
Q
-
-
E
T
K
T
G
E
L
N
S
R
L
S
S
D
T
T
L
M
S
N
W
L
P
L
N
A
N
V
L
L
R
S
L
V
K
V
V
G
L
Y
G
F
M
 285
ABCB4 135
V
S
-
-
-
F
W
T
L
A
A
G
R
Q
I
R
K
I
R
Q
K
F
F
H
A
I
L
R
Q
E
I
G
W
F
D
-
-
I
N
D
T
T
E
L
N
T
R
L
T
D
D
I
S
K
I
S
E
G
I
G
D
K
V
G
M
F
F
Q
A
V
A
T
F
F
A
G
F
I
V
G
 209
ABCB4 773
G
F
-
-
-
T
F
G
K
A
G
E
I
L
T
R
R
L
R
S
M
A
F
K
A
M
L
R
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D
M
S
W
F
D
D
H
K
N
S
T
G
A
L
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T
R
L
A
T
D
A
A
Q
V
Q
G
A
T
G
T
R
L
A
L
I
A
Q
N
I
A
N
L
G
T
G
I
I
I
S
 849
ABCB5 309
G
L
-
-
-
F
Y
G
R
A
G
E
I
L
T
M
R
L
R
H
L
A
F
K
A
M
L
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G
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L
A
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D
I
A
Q
I
Q
G
A
T
G
S
R
I
G
V
L
T
Q
N
A
T
N
M
G
L
S
V
I
I
S
 385
ABCB6 328
N
L
R
T
F
L
W
I
R
V
Q
Q
F
T
S
R
R
V
E
L
L
I
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L
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L
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L
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-
-
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L
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F
N
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T
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I
I
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I
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 405
ABCB7 208
E
V
R
N
A
V
F
G
K
V
A
Q
N
S
I
R
R
I
A
K
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L
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L
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L
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F
N
L
L
P
I
M
F
E
V
M
L
V
S
G
V
L
 285
ABCB8 210
F
G
Y
L
V
L
L
S
H
V
G
E
R
M
A
V
D
M
R
R
A
L
F
S
S
L
L
R
Q
D
I
T
F
F
D
-
-
A
N
K
T
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Q
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R
L
T
T
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F
K
S
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F
K
L
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I
S
Q
G
L
R
S
C
T
Q
V
A
G
C
L
V
S
L
 287
ABCB9 247
G
G
-
-
-
I
F
T
L
I
F
A
R
L
N
I
R
L
R
N
C
L
F
R
S
L
V
S
Q
E
T
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F
D
-
-
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N
R
T
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D
L
I
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L
T
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T
T
M
V
S
D
L
V
S
Q
N
I
N
V
F
L
R
N
T
V
K
V
T
G
V
V
V
F
M
 321
ABCB10 233
V
Y
-
-
-
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
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I
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R
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V
A
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N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
 307
ABCB11 817
G
Y
-
-
-
A
F
A
K
S
G
E
L
L
T
K
R
L
R
K
F
G
F
R
A
M
L
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D
I
A
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D
L
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A
L
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L
A
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D
A
S
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V
Q
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A
A
G
S
Q
I
G
M
I
V
N
S
F
T
N
V
T
V
A
M
I
I
A
 893