Mutations at homologous positions to ABCB1 p.Lys536

Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41

Mutations exactly at the same position:

Mutations +/- 5 a.a. around the position:

The alignment around the queried position:

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 848
ABCB1 498
D
E
-
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
K
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
V
A
L
D
K
-
 576
ABCB1 1143
E
E
-
I
V
R
A
A
K
E
A
N
I
H
A
F
I
E
S
L
P
N
K
Y
S
T
K
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
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R
Q
P
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I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
-
 1221
ABCB2 669
M
E
E
I
T
A
A
A
V
K
S
G
A
H
S
F
I
S
G
L
P
Q
G
Y
D
T
E
V
D
E
A
G
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Q
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Q
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L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
 748
ABCB3 573
D
D
K
V
M
A
A
A
Q
A
A
H
A
D
D
F
I
Q
E
M
E
H
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T
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K
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A
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Q
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P
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L
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L
D
E
A
T
S
A
L
D
V
-
-
-
-
Q
C
E
Q
A
L
Q
D
W
 648
ABCB4 500
D
E
-
I
K
K
A
V
K
E
A
N
A
Y
E
F
I
M
K
L
P
Q
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K
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I
A
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N
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K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
E
V
Q
A
A
L
D
K
-
 578
ABCB4 1149
D
E
-
I
V
S
A
A
K
A
A
N
I
H
P
F
I
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T
L
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K
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E
T
R
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G
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K
G
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G
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K
Q
R
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A
I
A
R
A
L
I
R
Q
P
Q
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
-
 1227
ABCB5 678
D
E
-
I
K
E
A
A
N
A
A
N
I
H
S
F
I
E
G
L
P
E
K
Y
N
T
Q
V
G
L
K
G
A
Q
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G
G
Q
K
Q
R
L
A
I
A
R
A
L
L
Q
K
P
K
I
L
L
L
D
E
A
T
S
A
L
D
N
D
S
E
K
V
V
Q
H
A
L
D
K
-
 756
ABCB6 693
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
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R
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G
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G
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A
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I
L
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D
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A
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S
A
L
D
T
S
N
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R
A
I
Q
A
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L
A
K
-
 772
ABCB7 575
P
E
E
V
Y
A
V
A
K
L
A
G
L
H
D
A
I
L
R
M
P
H
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A
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L
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A
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K
D
-
 654
ABCB8 578
D
E
E
V
Y
T
A
A
R
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A
N
A
H
E
F
I
T
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F
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T
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A
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D
A
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V
V
Q
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A
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D
R
-
 657
ABCB9 609
F
E
M
V
V
E
A
A
Q
K
A
N
A
H
G
F
I
M
E
L
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D
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L
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-
 688
ABCB10 600
A
E
E
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Q
R
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A
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V
A
N
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V
A
F
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R
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A
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A
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V
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-
 679
ABCB11 526
E
D
-
I
V
Q
A
A
K
E
A
N
A
Y
N
F
I
M
D
L
P
Q
Q
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D
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G
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G
G
G
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M
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-
 604
ABCB11 1186
E
R
-
V
I
A
A
A
K
Q
A
Q
L
H
D
F
V
M
S
L
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V
G
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G
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L
L
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D
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A
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A
L
D
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E
K
T
V
Q
V
A
L
D
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-
 1264