Mutations at homologous positions to ABCC7 p.Val350
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Val350Cys
p.Val350Ala
p.Val350Arg
|
D
N
?
D
N
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Val345Cys
p.Val345Ala
p.Val345Lys
p.Val345His
p.Val345Arg
p.Leu346Pro
p.Leu346Cys
p.Leu346Ala
p.Leu346Glu
p.Leu346Arg
p.Arg347Pro
p.Arg347Cys
p.Arg347His
p.Arg347Glu
p.Arg347Asp
p.Arg347Lys
p.Arg347Leu
p.Arg347Trp
p.Arg347Ile
p.Arg347Ala
p.Arg347Gln
p.Met348Lys
p.Met348Cys
p.Met348Val
p.Met348Thr
p.Met348Ala
p.Met348Arg
p.Met348Asn
p.Met348Ile
p.Met348Glu
p.Ala349Val
p.Ala349Cys
p.Ala349Ser
p.Ala349Lys
p.Thr351Ala
p.Thr351Cys
p.Thr351Ser
p.Thr351Arg
p.Arg352Gln
p.Arg352His
p.Arg352Cys
p.Arg352Glu
p.Arg352Trp
p.Arg352Lys
p.Arg352Ala
p.Arg352Gly
p.Gln353Cys
p.Gln353His
p.Gln353Ala
p.Gln353*
p.Phe354Ile
p.Phe354Arg
p.Pro355Ser
p.Pro355Leu
p.Pro355Ala
p.Pro355Phe
|
D
D
?
N
N
?
D
D
?
D
D
?
D
D
?
D
D
D
D
?
D
D
?
D
D
?
D
D
?
D
N
D
D
D
D
N
D
D
N
?
D
D
?
D
N
?
D
N
D
D
D
?
D
D
?
D
N
?
D
N
?
D
D
D
D
?
N
N
?
D
D
?
D
D
?
D
D
?
D
D
?
N
N
?
D
D
?
N
N
D
D
N
?
N
N
?
D
N
?
D
N
?
D
N
?
D
N
D
N
?
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
D
D
N
?
D
N
D
N
?
-
-
N
N
?
D
D
?
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCC1 |
p.Arg593Leu
p.Arg593Glu
p.Arg593Lys
p.Phe594Ala
p.Phe594Trp
p.Phe594Tyr
p.Pro595Ala
p.Asn597Ala
p.Pro600Ala
|
D
D
?
D
D
?
D
N
?
D
D
?
D
D
?
N
N
?
D
D
?
D
D
?
D
D
?
|
| ABCC2 |
p.Arg590Ala
|
D
D
?
|
| ABCC4 |
p.Thr364Arg
p.Phe368Leu
p.Phe368Trp
p.Phe368Tyr
p.Phe368Ala
|
D
D
?
N
D
?
D
D
?
N
N
?
N
D
?
|
| ABCC8 |
p.Val587Gly
p.Phe591Leu
|
N
D
?
N
D
?
|
The alignment around the queried position:
ABCC7 314
-
-
-
D
G
A
I
I
D
Q
K
K
T
E
Y
N
L
-
-
389
ABCC1 557
F
L
V
A
L
A
V
V
I
N
N
I
L
A
A
F
V
L
L
F
I
L
L
I
L
-
M
V
I
I
V
Q
A
S
V
S
L
K
R
L
R
I
F
L
S
H
E
E
L
E
P
D
S
I
R
P
V
635
ABCC2 554
P
V
L
V
S
V
V
T
S
V
Y
V
L
V
D
S
N
N
I
L
D
A
Q
A
F
T
S
I
T
L
F
N
I
L
F
P
L
S
M
L
P
-
M
M
I
S
S
M
L
Q
A
V
S
T
E
R
L
E
K
Y
L
G
G
D
D
L
D
T
S
A
I
R
H
D
C
N
632
ABCC3 543
P
F
L
V
T
I
L
W
V
Y
V
Y
V
D
P
N
N
V
L
D
A
E
K
A
F
V
S
V
S
L
F
N
I
L
R
L
P
L
N
M
L
P
-
Q
L
I
S
N
L
T
Q
A
S
V
S
L
K
R
I
Q
Q
F
L
Q
E
E
L
D
P
Q
S
V
E
R
K
T
I
621
ABCC4 328
S
K
I
I
V
F
V
T
F
T
T
Y
V
L
L
G
S
V
-
-
I
T
A
S
R
V
F
V
A
V
L
Y
G
A
V
R
L
V
T
L
F
P
S
A
I
V
S
A
I
V
S
I
R
R
I
Q
T
F
L
L
L
D
E
I
S
Q
R
N
R
Q
L
S
D
405
ABCC5 410
V
V
I
A
S
V
V
T
F
S
V
H
M
T
L
G
F
D
-
-
L
T
A
A
Q
A
F
T
V
V
T
V
F
N
S
M
T
F
A
L
K
V
T
P
-
F
S
V
K
S
L
S
E
A
S
V
A
V
D
R
F
K
S
L
F
L
M
E
E
V
H
M
I
K
N
K
P
A
S
P
486
ABCC6 543
T
F
L
V
A
L
V
V
F
A
V
H
T
L
V
A
E
N
-
A
N
A
E
K
A
V
T
L
T
V
L
N
I
L
N
K
A
Q
A
F
L
P
-
F
I
H
S
L
V
Q
A
R
V
S
F
D
L
V
T
F
L
C
L
E
E
V
D
P
G
V
D
S
S
S
S
620
ABCC8 551
I
A
V
L
I
T
F
H
V
S
F
A
D
F
S
P
V
A
F
A
S
S
F
H
I
L
T
P
L
L
L
S
-
S
V
V
S
T
K
A
L
V
S
Q
K
L
S
E
F
L
S
S
A
E
I
E
E
Q
C
A
P
H
E
P
629
ABCC9 547
P
I
A
A
V
L
A
T
F
V
T
H
A
-
Y
A
S
G
N
N
L
K
P
A
E
A
F
A
S
L
S
L
F
H
I
L
V
T
P
L
F
L
L
S
-
T
V
V
R
A
V
K
A
I
I
S
V
Q
K
L
N
E
F
L
L
S
D
E
I
G
D
D
S
W
R
T
G
E
S
624
ABCC10 514
P
V
V
I
S
I
V
I
F
I
T
Y
V
L
M
G
H
Q
-
-
L
T
A
T
K
V
F
T
A
L
A
L
V
R
M
L
I
L
P
L
N
N
F
P
-
W
V
I
N
G
L
L
E
A
K
V
S
L
D
R
I
Q
L
F
L
D
L
P
N
H
N
P
Q
A
Y
Y
S
-
P
D
589
ABCC11 394
P
T
V
A
T
A
V
W
V
L
I
H
T
S
L
K
L
K
-
-
L
T
A
S
M
A
F
S
M
L
A
S
L
N
L
L
R
L
S
V
F
F
V
P
-
I
A
V
K
G
L
T
N
S
K
S
A
V
M
R
F
K
K
F
F
L
Q
E
S
P
V
F
Y
V
Q
T
L
Q
D
P
470
ABCC12 354
S
T
I
A
I
V
L
T
L
S
C
H
I
L
L
R
R
K
-
-
L
T
A
P
V
A
F
S
V
I
A
M
F
N
V
M
K
F
S
I
A
I
L
P
-
F
S
I
K
A
M
A
E
A
N
V
S
L
R
R
M
K
K
I
L
I
D
K
S
P
P
S
Y
I
T
Q
P
E
D
P
430