ABCC8 p.Glu128Trp

Predicted by SNAP2: A: D (66%), C: D (59%), D: D (85%), F: D (71%), G: D (85%), H: D (80%), I: D (75%), K: D (71%), L: D (75%), M: D (66%), N: D (85%), P: D (91%), Q: D (75%), R: D (80%), S: D (80%), T: D (80%), V: D (75%), W: D (80%), Y: D (71%),
Predicted by PROVEAN: A: D, C: D, D: N, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: N, R: D, S: D, T: D, V: D, W: D, Y: D,

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[hide] Pratt EB, Tewson P, Bruederle CE, Skach WR, Shyng SL
N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2.
J Gen Physiol. 2011 Mar;137(3):299-314. Epub 2011 Feb 14., [PMID:21321069]

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[hide] Pratt EB, Shyng SL
ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP2 sensitivity.
Channels (Austin). 2011 Jul-Aug;5(4):314-9. doi: 10.4161/chan.5.4.16510. Epub 2011 Jul 1., [PMID:21654216]

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