Mutations at homologous positions to ABCC7 p.Gly1127
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Gly1127Glu
p.Gly1127Cys
|
D
D
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Thr1122Cys
p.Gly1123Arg
p.Glu1124Arg
p.Glu1124Cys
p.Glu1126Arg
p.Glu1126Cys
p.Arg1128Glu
p.Arg1128Gln
p.Arg1128*
p.Arg1128Gly
p.Val1129Cys
p.Gly1130Ala
p.Ile1131Val
p.Ile1131Cys
p.Ile1131Leu
p.Ile1132Cys
|
D
N
?
N
N
D
N
?
N
N
?
D
N
?
N
N
?
N
N
?
N
N
?
-
-
D
N
?
N
D
?
D
D
N
N
?
N
D
?
N
N
?
N
N
?
|
| ABCC1 |
p.Ala1227Lys
p.Ser1233Ala
|
D
N
?
N
N
?
|
| ABCC12 |
p.Gly1057Ala
|
D
D
?
|
| ABCC3 |
p.Ser1219Arg
p.Ser1229Ala
|
N
N
?
N
N
?
|
| ABCC6 |
p.Gly1203Asp
|
D
D
D
|
| ABCC9 |
p.Gly1249Ala
|
D
D
?
|
The alignment around the queried position:
ABCC7 1091
L
S
T
R
I
I
-
-
-
G
S
M
V
V
F
F
I
1167
ABCC1 1191
S
I
V
A
N
L
A
V
L
V
I
V
L
A
A
L
F
A
V
I
S
H
S
-
-
L
S
G
L
V
G
L
V
L
V
L
L
V
M
S
S
E
M
E
T
N
I
V
A
V
E
R
L
K
E
S
1268
ABCC2 1199
S
W
I
T
S
N
R
W
L
A
I
L
E
L
V
G
N
L
T
V
F
F
S
A
L
M
M
V
I
Y
D
T
-
-
L
S
G
D
T
V
G
F
V
L
S
A
L
N
I
T
Q
T
L
N
L
V
M
T
S
E
I
E
T
N
I
V
A
V
E
R
I
E
T
1276
ABCC3 1187
P
Y
I
I
S
N
R
W
L
S
I
G
V
E
F
V
G
N
C
V
V
L
F
A
A
L
F
A
V
I
G
R
S
-
-
L
N
P
G
L
V
G
L
V
L
V
F
A
L
M
I
R
M
M
S
D
L
E
S
N
I
V
A
V
E
R
V
K
E
Y
S
1264
ABCC4 940
L
F
L
T
T
S
R
W
F
A
V
R
L
D
A
I
A
M
F
V
I
I
V
A
F
G
S
L
I
L
A
K
T
-
-
L
D
A
G
Q
V
G
L
A
L
S
Y
A
L
T
L
M
G
M
F
Q
C
V
Q
S
A
E
V
E
N
M
M
I
S
V
E
R
V
I
E
Y
T
1017
ABCC5 1090
L
F
T
C
A
M
W
L
A
V
R
L
D
L
I
S
I
A
L
I
T
T
T
G
L
M
I
V
L
M
H
G
Q
-
-
I
P
P
A
Y
A
G
L
A
I
S
Y
A
V
Q
L
T
G
L
F
Q
F
T
V
R
L
A
S
E
T
E
A
R
F
T
S
V
E
R
I
N
H
Y
I
1167
ABCC6 1163
P
L
V
A
D
R
W
L
A
A
N
V
E
L
L
G
N
L
V
F
A
A
A
T
C
A
V
L
S
K
A
H
-
-
L
S
A
G
L
V
F
S
V
S
A
A
L
Q
V
T
Q
T
L
Q
W
V
V
N
T
D
E
N
S
I
V
S
V
M
A
1240
ABCC8 1239
F
L
T
A
A
N
R
W
L
E
M
E
Y
G
C
V
V
I
A
V
T
S
I
S
N
S
L
H
R
E
L
S
A
G
L
V
G
L
G
L
Y
A
L
S
N
Y
L
N
W
M
V
R
N
L
A
D
M
L
Q
L
G
A
V
K
R
I
H
L
L
1318
ABCC9 1211
F
L
S
A
A
N
R
W
L
E
V
R
T
D
Y
L
G
A
C
I
V
L
T
A
S
I
A
S
I
S
G
S
S
N
-
-
-
-
S
G
L
V
L
G
L
L
Y
A
L
T
I
T
N
Y
L
N
W
V
V
R
N
L
A
D
L
E
V
Q
M
G
A
V
K
K
V
N
S
F
L
1286
ABCC10 1143
A
T
S
A
T
M
Q
W
L
D
I
R
L
Q
L
M
G
A
A
V
V
S
A
I
A
G
I
A
L
V
Q
H
Q
Q
G
L
A
N
P
G
L
V
G
L
S
L
S
A
L
S
L
T
G
L
L
S
G
L
V
S
S
F
T
Q
T
E
A
M
L
V
S
V
E
R
L
E
E
Y
T
1222
ABCC11 1038
L
F
L
S
S
T
R
W
M
A
L
R
L
E
I
M
T
N
L
V
T
L
A
V
A
L
F
V
A
F
G
I
S
S
-
-
T
P
Y
S
F
K
V
M
A
V
N
I
V
L
L
A
S
S
F
Q
A
T
A
I
G
L
E
T
E
A
Q
F
T
A
V
E
R
I
L
Q
Y
M
1115
ABCC12 1017
Y
F
N
C
A
L
R
W
F
A
L
R
M
D
V
L
M
N
I
L
T
F
T
V
A
L
L
V
T
L
S
F
S
S
-
-
I
S
T
S
S
K
L
S
L
S
Y
I
I
Q
L
S
G
L
L
Q
V
C
V
R
T
G
T
E
T
Q
A
K
F
T
S
V
E
L
L
R
E
Y
I
1094