ABCMdb

PMID: 9379168

Linsdell P, Tabcharani JA, Rommens JM, Hou YX, Chang XB, Tsui LC, Riordan JR, Hanrahan JW
Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions.
J Gen Physiol. 1997 Oct;110(4):355-64., [PubMed]

Sentences

No. Mutations Sentence Comment

13 ABCC7 p.Arg334Trp ABCC7 p.Arg347Pro ABCC7 p.Arg347His Some of these low conductance mutations (R334W, R347P, and R347H) occur in cystic fibrosis patients and have been associated with relatively mild disease symptoms. Login to comment 17 ABCC7 p.Arg334Trp ABCC7 p.Arg347Pro ABCC7 p.Arg347His Some of these low conductance mutations (R334W, R347P, and R347H) occur in cystic fibrosis patients and have been associated with relatively mild disease symptoms. Login to comment 171 ABCC7 p.Ser341Ala In contrast, mutating serine 341 to alanine produced outward rectification of the i/V relationship, consistent with its proposed role as a binding site for permeating anions (McDonough et al., 1994). Login to comment 192 ABCC7 p.Ser341Ala In contrast, mutating serine 341 to alanine produced outward rectification of the i/V relationship, consistent with its proposed role as a binding site for permeating anions (McDonough et al., 1994). Login to comment