PMID: 8549739

Senior AE, al-Shawi MK, Urbatsch IL
The catalytic cycle of P-glycoprotein.
FEBS Lett. 1995 Dec 27;377(3):285-9., [PubMed]
Sentences
No. Mutations Sentence Comment
67 ABCB1 p.Phe978Ala
X
ABCB1 p.Phe978Ala 8549739:67:70
status: NEW
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 These included F335A~ which gave considerable increase in ATPase, and F978A which gave large decrease. Login to comment 68 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 8549739:68:7
status: NEW
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ABCB1 p.Gly830Val
X
ABCB1 p.Gly830Val 8549739:68:17
status: NEW
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ABCB1 p.Gly141Val
X
ABCB1 p.Gly141Val 8549739:68:0
status: NEW
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 G141V, G185V and G830V caused relative changes in degree of activation of ATPase by vinblastine, verapamil and colchic- inc. Login to comment 69 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 8549739:69:21
status: NEW
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 Rao [35] studied the G185V mutation in human Pgp using the membrane fraction from St9 cells, and obtained similar results. Login to comment 103 ABCB1 p.Lys1076Met
X
ABCB1 p.Lys1076Met 8549739:103:78
status: NEW
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ABCB1 p.Lys433Met
X
ABCB1 p.Lys433Met 8549739:103:71
status: NEW
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ABCB1 p.Gly432Ser
X
ABCB1 p.Gly432Ser 8549739:103:86
status: NEW
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ABCB1 p.Gly1075Ser
X
ABCB1 p.Gly1075Ser 8549739:103:96
status: NEW
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 Loo and Clarke [37] extended this approach, showing that the mutations K433M, K1076M, G432S and G1075S in the Homology A sequences of either NBS1 or NBS2 in human Pgp abolish drug-exclusion capability in cells and eliminate ATPase activity in membranes. Login to comment