ABCMdb

PMID: 23707894

Doliwa C, Escotte-Binet S, Aubert D, Sauvage V, Velard F, Schmid A, Villena I
Sulfadiazine resistance in Toxoplasma gondii: no involvement of overexpression or polymorphisms in genes of therapeutic targets and ABC transporters.
Parasite. 2013;20:19. doi: 10.1051/parasite/2013020. Epub 2013 May 27., [PubMed]

Sentences

No. Mutations Sentence Comment

28 ABCC1 p.Lys540Glu Resistance to sulfonamides and sulfones has been demonstrated to result from mutations within DHPS, such as amino acid changes at five positions (S436A/F, A437G, K540E, A581G, A613/T) [2]. Login to comment 58 ABCC1 p.Ala587Val In the resistant strain TgH 32006, one mutation converting Alanine to Valine at position 587 was found in exon 5 [7]. Login to comment 84 ABCC1 p.Ala587Val ABCC1 p.Thr665Ser Genotype Sulfadiazine susceptibility TgABC.B1 TgABC.B2 TgABC.C1 dhps dhfr RH I Sensitive * (20) T9A,K1285Q EU213065.1 * (22) S2N, S267N, G368D, I509T, L729M, M848L, L883I EF418617.1 * (19) K7E, D491E, T665S G672E, H954P, G968A E1125A, S1718R V1722A, P1785S FJ201251.1 *(2) E474K, R560K A597E *(1) PRU II Sensitive 0 0 0 0 0 EU213066.1 EF418618.1 FJ201252.1 GQ415579.1 GQ397454.1 NED III Sensitive * (13) 0 0 0 0 T9A,K1285Q EU213067.1 EF418619.1 FJ201253.1 GQ415579.1 GQ397454.1 TgA 103001 I Resistant * (19) T9A, K1285Q FJ201255.1 * (23) S2N, S267N, G368D, I509T, G816E, M848L, L883I FJ201256.1 * (23) K7E, D491E, G782A H954P, G968A E1125A, G1440A, H1659Q, S1718R, V1722A, P1785S FJ201254.1 * (2) E474K, R560K, A597E GQ415574.1 * (1) GQ415574.1 TgH 32006 II Resistant 0 0 0 A587V 0 FJ201257.1 FJ215662.1 GQ865628.1 GQ865628.1 GQ397458.1 TgH 32045 II Variant Resistant * (1) *(1) L729M K642E, H1659Q 0 0 FJ201258.1 GQ865630.1 GQ865629.1 GQ415580.1 GQ397459.1 of expression for the TgABC.B2 gene. Login to comment