PMID: 22869929

Huang L, Be X, Tchaparian EH, Colletti AE, Roberts J, Langley M, Ling Y, Wong BK, Jin L
Deletion of abcg2 has differential effects on excretion and pharmacokinetics of probe substrates in rats.
J Pharmacol Exp Ther. 2012 Nov;343(2):316-24. doi: 10.1124/jpet.112.197046. Epub 2012 Aug 6., [PubMed]
Sentences
No. Mutations Sentence Comment
15 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 22869929:15:82
status: NEW
view ABCG2 p.Gln141Lys details
 ABCG2 421CϾA SNP results in a lysine to glutamine acid change at codon 141 (Q141K), which leads to decreased protein expression level or reduced drug resistance to anticancer agents in transfected cells (Imai et al., 2002; Mizuarai et al., 2004; Morisaki et al., 2005; Tamura Article, publication date, and citation information can be found at http://jpet.aspetjournals.org. Login to comment 21 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 22869929:21:4
status: NEW
view ABCG2 p.Gln141Lys details
 The Q141K variant was associated with increased risk for gefitinib-induced diarrhea (Cusatis et al., 2006). Login to comment 24 ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 22869929:24:35
status: NEW
view ABCG2 p.Val12Met details
ABCG2 p.Pro269Ser
X
ABCG2 p.Pro269Ser 22869929:24:55
status: NEW
view ABCG2 p.Pro269Ser details
 Several additional SNPs, including V12M, Q126Stop, and P269S, affect expression or activities of the transporter, which may also have clinical implications (Kondo et al., 2004; Mizuarai et al., 2004; Tamura et al., 2006; Lee et al., 2007). Login to comment