ABCMdb

PMID: 22859919

Chan J, Vandeberg JL
Hepatobiliary transport in health and disease.
Clin Lipidol. 2012 Apr;7(2):189-202., [PubMed]

Sentences

No. Mutations Sentence Comment

84 ABCB11 p.Asp482Gly ABCB11 p.Glu297Gly The most common mutations are E297G and D482G [26]. Login to comment 85 ABCB11 p.Asp482Gly ABCB11 p.Asp482Gly ABCB11 p.Glu297Gly The disease progresses more slowly in patients with D482G mutations, and they develop cirrhosis at an older age [24]. Login to comment 86 ABCB11 p.Asp482Gly The disease progresses more slowly in patients with D482G mutations, and they develop cirrhosis at an older age [24]. Login to comment 91 ABCB11 p.Val444Ala The V444A polymorphism is associated with susceptibility to drug-induced cholestasis and has been shown to be associated with lower ABCB11 expression levels. Login to comment 92 ABCB11 p.Val444Ala The V444A polymorphism is associated with susceptibility to drug-induced cholestasis and has been shown to be associated with lower ABCB11 expression levels. Login to comment 94 ABCB11 p.Val444Ala The V444A variant is also associated with ICP type 2 patients [28]. Login to comment 95 ABCB11 p.Val444Ala The V444A variant is also associated with ICP type 2 patients [28]. Login to comment