PMID: 21929509

Semsei AF, Erdelyi DJ, Ungvari I, Csagoly E, Hegyi MZ, Kiszel PS, Lautner-Csorba O, Szabolcs J, Masat P, Fekete G, Falus A, Szalai C, Kovacs GT
ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia.
Cell Biol Int. 2012 Jan;36(1):79-86., [PubMed]
Sentences
No. Mutations Sentence Comment
121 ABCC1 p.Gly671Val
X
ABCC1 p.Gly671Val 21929509:121:310
status: NEW
view ABCC1 p.Gly671Val details
ABCC2 p.Cys1515Tyr
X
ABCC2 p.Cys1515Tyr 21929509:121:369
status: NEW
view ABCC2 p.Cys1515Tyr details
ABCC2 p.Val1188Glu
X
ABCC2 p.Val1188Glu 21929509:121:358
status: NEW
view ABCC2 p.Val1188Glu details
 This study found an association between chronic anthracycline-induced cardiotoxicity and a polymorphism in the NAD(P)H oxidase subunit NFC4 (rs1883112), and between: acute anthracycline-induced cardiotoxicity and the NAD(P)H oxidase subunits CYBA (rs4673) and RAC2 (rs1305 8338); and the ABC transporter ABCC1 Gly671Val variant (which is rs45511401) and the Val1188Glu-Cys1515Tyr (rs8187694- rs8187710) haplotype of the ABCC2 gene. Login to comment