ABCMdb

PMID: 21128988

Wei KK, Zhang LR, Zhang Y, Hu XJ
Interactions between CYP7A1 A-204C and ABCG8 C1199A polymorphisms on lipid lowering with atorvastatin.
J Clin Pharm Ther. 2010 Dec 3. doi: 10.1111/j.1365-2710.2010.01227.x., 2010-12-03 [PubMed]

Sentences

No. Mutations Sentence Comment

23 ABCG8 p.Asp19His More recently, the ABCG8 D19H polymorphism was found to be significantly associated with increased reduction in LDL-C level after atorvastatin treatment (14). Login to comment 27 ABCG5 p.Gln604Glu ABCG8 p.Asp19His ABCG8 p.Thr400Lys ABCG8 p.Tyr54Cys Several previous studies have found that 5 nonsynonymous single-nucleotide polymorphisms in the ABCG5 (Q604E) and ABCG8 (D19H, Y54C, T400K, A632V) coding sequences may affect plasma plant sterol or cholesterol levels (16-19). Login to comment 29 ABCG8 p.Thr400Lys ABCG8 p.Tyr54Cys Allele frequencies of 19H and 632V were found to be rare in a Chinese population (20), and the Y54C and T400K alleles showed strong linkage disequilibrium. Login to comment 30 ABCG8 p.Thr400Lys Therefore, we investigated the effect of the interactions between the CYP7A1 A-204C and ABCG8 C1199A (T400K) polymorphisms on lipid-lowering with atorvastatin treatment in a Chinese population. Login to comment 88 ABCG8 p.Thr400Lys However, these findings are inconsistent with those of Kajinami et al., who found homozygotes for both CYP7A1 A-204 and ABCG8 19H alleles with increased reduction in LDL-C level and ABCG8 T400K polymorphism without an important interaction with CYP7A1 polymorphism (15). Login to comment