ABCMdb

PMID: 20837481

Pagant S, Halliday JJ, Kougentakis C, Miller EA
Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter.
J Biol Chem. 2010 Nov 19;285(47):36304-14. Epub 2010 Sep 13., 2010-11-19 [PubMed]

Sentences

No. Mutations Sentence Comment

84 ABCC7 p.Gly149Arg ABCC7 p.Leu1065Pro We selected two mutations (G149R, located at the start of ICL1, and L1065P, located in ICL4 and predicted to participate directly in the NBD1-ICL4 interface) and introduced the equivalent mutations into Yor1p (Fig. 1A): Yor1p-G278R and Yor1p-I1084P, respectively. Login to comment 249 ABCC7 p.Ile539Thr ABCC7 p.Gly550Glu ABCC7 p.Arg553Met ABCC7 p.Arg555Lys Remarkably, all suppressing mutations identified (I539T, G550E, R553M, and R555K) by this study are located within the NBD1 domain itself. Login to comment