ABCMdb

PMID: 20170916

Abellan R, Mansego ML, Martinez-Hervas S, Martin-Escudero JC, Carmena R, Real JT, Redon J, Castrodeza-Sanz JJ, Chaves FJ
Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from the population-based Hortega study.
Atherosclerosis. 2010 Jul;211(1):203-9. Epub 2010 Jan 29., [PubMed]

Sentences

No. Mutations Sentence Comment

2 ABCA1 p.Arg219Lys In men, subjects with the AA genotype of the ABCA1 rs2230806 (R219K) polymorphism were associated with increased plasma LDLc levels, while the ABCA1 haplotype, which included the rs2230806 A allele, was associated with higher TC and LDLc plasma concentrations. Login to comment 81 ABCA1 p.Arg219Lys ABCA1 gene polymorphisms In the total population, the rs2230806 (R219K) polymorphism in gene ABCA1 was associated with plasma LDLc levels (p = 0.046) (Table 2). Login to comment 123 ABCA1 p.Arg219Lys The R219K variant (rs2230806 polymorphism) has been recognized as putative antiatherogenic polymorphisms, and the K219 form (A allele) has been associated with increased HDLc levels [10,11,24]. Login to comment 142 ABCG8 p.Tyr54Cys For the studied polymorphisms of the ABCG5 and ABCG8 genes, only rs4148211 (ABCG8 Y54C) obtained significant associations with the TC and LDLc plasma levels in the total population, even after adjusting for total caloric intake or lipid consumption. Login to comment 144 ABCG8 p.Tyr54Cys For the studied polymorphisms of the ABCG5 and ABCG8 genes, only rs4148211 (ABCG8 Y54C) obtained significant associations with the TC and LDLc plasma levels in the total population, even after adjusting for total caloric intake or lipid consumption. Login to comment 147 ABCG8 p.Tyr54His Regarding the Y54H polymorphism, diverging results have been observed in previous studies for associations with lipid levels [13,14,16,18,19]; these divergences in the results could be related with the degree of the reduction of total plasma cholesterol and LDLc with dietary changes [13]. Login to comment 148 ABCG8 p.Tyr54Cys In spite of the feed status, which makes comparisons between studies on lipid levels more difficult, to our knowledge, no variations in LDLc levels directly related with the Y54C polymorphism have been observed. Login to comment 149 ABCG8 p.Thr400Lys ABCG8 p.Tyr54Cys ABCG8 p.Tyr54His Regarding the Y54H polymorphism, diverging results have been observed in previous studies for associations with lipid levels [13,14,16,18,19]; these divergences in the results could be related with the degree of the reduction of total plasma cholesterol and LDLc with dietary changes [13]. Login to comment 150 ABCG8 p.Tyr54Cys In spite of the feed status, which makes comparisons between studies on lipid levels more difficult, to our knowledge, no variations in LDLc levels directly related with the Y54C polymorphism have been observed. Login to comment 151 ABCG8 p.Thr400Lys ABCG8 p.Tyr54Cys However, Wang et al. [17] found higher but not significant plasma LDLc levels for carriers of the less frequent K allele of ABCG8 T400K, which was in strong linkage disequilibrium with the SNP Y54C of ABCG8. Login to comment