ABCMdb

PMID: 18641716

Rudkowska I, AbuMweis SS, Nicolle C, Jones PJ
Association between non-responsiveness to plant sterol intervention and polymorphisms in cholesterol metabolism genes: a case-control study.
Appl Physiol Nutr Metab. 2008 Aug;33(4):728-34., [PubMed]

Sentences

No. Mutations Sentence Comment

112 ABCG8 p.Thr400Lys In general, results show that all subjects were homozygous for all ABCG5/G8 polymorphisms, except for 1 non-responder, who was heterozygous for A632V (rs6544718) and T400K (rs414817) in the ABCG8 transporters. Login to comment 114 ABCG8 p.Thr400Lys Hubacek et al. (2004) showed that T400K in the ABCG8 gene associates with changes in lipid levels in males in response to reduced dietary animal fat and cholesterol intake. Login to comment 115 ABCG8 p.Thr400Lys In particular, males had greater reductions of TC with the wild-type allele than with the mutant allele of the T400K in the ABCG8 gene. Login to comment 117 ABCG8 p.Thr400Lys In addition, Plat et al. (2005) showed that cholesterol-standardized serum PS concentrations, as well as changes in serum PS concentrations after consumption of PS, were associated with the ABCG8 T400K genotype. Login to comment 118 ABCG8 p.Thr400Lys However, similar to the present study, no associations were seen between any common variations in T400K with lipids responsiveness to PS intervention (Plat et al. 2005). Login to comment 119 ABCG5 p.Gln604Glu In addition, a previous study by Weggemans et al. (2002), determined that subjects with the ABCG5 Q604E (rs6720173) mutant allele genotype had higher baseline TC levels than subjects with the wild-type allele, even if the response to dietary interventions was not related to this specific genotype. Login to comment 121 ABCG5 p.Gln604Glu In agreement with our study, the previous investigations (Kajinami et al. 2004b; Weggemans et al. 2002; Gylling et al. 2004) failed to identify any associations between ABCG5 Q604E and plasma lipid responses to PS intervention. Login to comment 122 ABCG8 p.Asp19His Furthermore, two studies showed an association between the ABCG8 D19H (rs11887534) polymorphism and the proportional reduction in LDL-C during statin intervention (Kajinami et al. 2004b; Gylling et al. 2004). Login to comment 124 ABCG8 p.Met429Val Also, the M429V SNP in ABCG8 was reported to participate in cholesterol absorption efficiency in the Japanese population (Miwa et al. Fig. 3. Login to comment