ABCMdb

PMID: 18468402

Ergen A, Isbir S, Tekeli A, Isbir T
Investigation of ABCA1 C69T and G-191C polymorphisms in coronary artery disease.
In Vivo. 2008 Mar-Apr;22(2):187-90., [PubMed]

Sentences

No. Mutations Sentence Comment

21 ABCA1 p.Ile883Met Martin et al. analyzed three polymorphisms of the ABCA1 gene (-477C/T, R219 K and I883M) in a cohort of young male survivors of MI in order to assess the influence of these polymorphisms on long-term prognosis (12). Login to comment 63 ABCA1 p.Ile883Met Jensen et al. indicated that the I883M variant was associated with higher HDL-cholesterol levels among younger women, with the -565C/T and the -191G/C variants being inversely associated with the risk of CHD among healthy women, without pronounced effects on plasma lipids (17). Login to comment 74 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys ABCA1 p.Val771Met They found that the rare alleles of C-14T(C69T) and V771M polymorphisms were associated with higher HDL-C levels in men and, in combination with the rare alleles of R219K and I883M, respectively, with higher HDL-C in both sexes. Login to comment 75 ABCA1 p.Arg219Lys ABCA1 p.Glu1172Asp In another study of six common polymorphisms of ABCA1, very high HDL-C was found to be associated with a higher genotype frequency for R219K and higher genotype and allelic frequency for E1172D compared with lower HDL-C (21). Login to comment 79 ABCA1 p.Arg219Lys They suggested that R219K polymorphism in Ergen et al: Investigation of ABCA1 C69T and G-191C Polymorphisms in Coronary Artery Disease 189 Table III. Login to comment