PMID: 1717452

Shyamala V, Baichwal V, Beall E, Ames GF
Structure-function analysis of the histidine permease and comparison with cystic fibrosis mutations.
J Biol Chem. 1991 Oct 5;266(28):18714-9., [PubMed]
Sentences
No. Mutations Sentence Comment
159 ABCC7 p.Pro574His
X
ABCC7 p.Pro574His 1717452:159:79
status: NEW
view ABCC7 p.Pro574His details
ABCC7 p.Ala455Glu
X
ABCC7 p.Ala455Glu 1717452:159:62
status: NEW
view ABCC7 p.Ala455Glu details
ABCC7 p.Gly458Val
X
ABCC7 p.Gly458Val 1717452:159:68
status: NEW
view ABCC7 p.Gly458Val details
 A few mutations are located in the nucleotide-binding pocket, A455E,G458V, and P574H, and may be tolerated because they may have maintained partial activity, especially the two that are not located insites defined as critical for ATP binding by the HisPanalysis. Login to comment