PMID: 17093005

Enokizono J, Kusuhara H, Sugiyama Y
Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
Drug Metab Dispos. 2007 Feb;35(2):209-14. Epub 2006 Nov 8., [PubMed]
Sentences
No. Mutations Sentence Comment
192 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 17093005:192:97
status: NEW
view ABCG2 p.Gln141Lys details
ABCG2 p.Ser441Asn
X
ABCG2 p.Ser441Asn 17093005:192:117
status: NEW
view ABCG2 p.Ser441Asn details
ABCG2 p.Gln126*
X
ABCG2 p.Gln126* 17093005:192:79
status: NEW
view ABCG2 p.Gln126* details
ABCG2 p.Gln126*
X
ABCG2 p.Gln126* 17093005:192:79
status: NEW
view ABCG2 p.Gln126* details
 BCRP has some functional single nucleotide polymorphisms (SNP), such as C376T (Q126stop), C421A (Q141K), and G1322A (S441N). Login to comment