PMID: 16454695

Tian Q, Zhang J, Chan SY, Tan TM, Duan W, Huang M, Zhu YZ, Chan E, Yu Q, Nie YQ, Ho PC, Li Q, Ng KY, Yang HY, Wei H, Bian JS, Zhou SF
Topotecan is a substrate for multidrug resistance associated protein 4.
Curr Drug Metab. 2006 Jan;7(1):105-18., [PubMed]
Sentences
No. Mutations Sentence Comment
47 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 16454695:47:212
status: VERIFIED
view ABCG2 p.Gln141Lys details
ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 16454695:47:206
status: VERIFIED
view ABCG2 p.Val12Met details
ABCG2 p.Asp620Asn
X
ABCG2 p.Asp620Asn 16454695:47:222
status: VERIFIED
view ABCG2 p.Asp620Asn details
 However, resistance levels of TPT are inconsistent in different BCRP overexpressing cell lines [51-59], probably due to the existence of three mutant variants of BCRP resulting in the amino acid changes at V12M, Q141K and D620N [63-67]. Login to comment