ABCMdb

PMID: 16207707

Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
J Biol Chem. 2005 Dec 30;280(52):43243-56. Epub 2005 Oct 5., [PubMed]

Sentences

No. Mutations Sentence Comment

335 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Wollmer et al. (74) reported that the R219K gain-of-function single nucleotide polymorphism in ABCA1 (R219K) has been suggested to delay the age of onset of AD by 1.6 years. Login to comment 336 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys ABCA1 p.Val771Met Katzov et al. (75) reported significant associations with the R219K, R1587K, and V771M on AD in single marker and haplotype analyses conducted on European subjects. Login to comment 337 ABCA1 p.Arg219Lys ABCA1 p.Val771Met Katzov et al. (75) reported significant associations with the R219K, R1587K, and V771M on AD in single marker and haplotype analyses conducted on European subjects. Login to comment