ABCMdb

PMID: 15684079

Randak CO, Welsh MJ
ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2216-20. Epub 2005 Jan 31., 2005-02-08 [PubMed]

Sentences

No. Mutations Sentence Comment

31 ABCC7 p.Lys1250Ala ABCC7 p.Asp1370Asn For example, structural studies predict that the K1250A and D1370N mutations alter the ATP-binding sites, and these mutations disrupted both ATPase activity and adenylate kinase activities, as well as ADP-dependent inhibition. Login to comment 32 ABCC7 p.Asn1303Lys In contrast, the N1303K mutation is predicted to lie outside the ATP-binding site. Login to comment