PMID: 11404246

Choo-Kang LR, Zeitlin PL
Induction of HSP70 promotes DeltaF508 CFTR trafficking.
Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L58-68., [PubMed]
Sentences
No. Mutations Sentence Comment
109 ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 11404246:109:41
status: NEW
view ABCC7 p.Trp1282* details
ABCC7 p.Trp1282*
X
ABCC7 p.Trp1282* 11404246:109:97
status: NEW
view ABCC7 p.Trp1282* details
 IB3-1 has the CFTR genotype ⌬F508/W1282X but expresses only ⌬F508 CFTR because the W1282X mutation produces an unstable, and therefore untranslated, mRNA (27, 28). Login to comment 281 ABCC7 p.Pro574His
X
ABCC7 p.Pro574His 11404246:281:106
status: NEW
view ABCC7 p.Pro574His details
ABCC7 p.Asn1303Lys
X
ABCC7 p.Asn1303Lys 11404246:281:98
status: NEW
view ABCC7 p.Asn1303Lys details
ABCC7 p.Gly480Cys
X
ABCC7 p.Gly480Cys 11404246:281:116
status: NEW
view ABCC7 p.Gly480Cys details
 Whether this approach would also overcome the defects caused by other trafficking mutants such as N1303K, P574H, or G480C remains to be tested. Login to comment