PMID: 10398692

Weinreich F, Riordan JR, Nagel G
Dual effects of ADP and adenylylimidodiphosphate on CFTR channel kinetics show binding to two different nucleotide binding sites.
J Gen Physiol. 1999 Jul;114(1):55-70., [PubMed]
Sentences
No. Mutations Sentence Comment
324 ABCC7 p.Lys1250Ala
X
ABCC7 p.Lys1250Ala 10398692:324:184
status: NEW
view ABCC7 p.Lys1250Ala details
ABCC7 p.Lys464Ala
X
ABCC7 p.Lys464Ala 10398692:324:175
status: NEW
view ABCC7 p.Lys464Ala details
 Their conclusions were derived from studying the gating (temperature not specified) and the ATPase activity (at 30ЊC) of purified CFTR protein, either WT or the mutants K464A or K1250A. Login to comment 325 ABCC7 p.Lys1250Ala
X
ABCC7 p.Lys1250Ala 10398692:325:65
status: NEW
view ABCC7 p.Lys1250Ala details
 However, in contrast to their open burst duration for the mutant K1250A of 265 ms (temperature not specified) are dramatically increased open burst durations found by other groups (65 s for Gunderson and Kopito, 1995; 3 min for Zeltwanger et al., 1999; both at room temperature). Login to comment 326 ABCC7 p.Lys1250Ala
X
ABCC7 p.Lys1250Ala 10398692:326:54
status: NEW
view ABCC7 p.Lys1250Ala details
 Carson et al. (1995) found an open burst duration for K1250A at 34-36ЊC of ‫1ف‬ s. Login to comment