PMID: 7912913

Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli CO, Pastan I
Gene transfer of drug resistance genes. Implications for cancer therapy.
Ann N Y Acad Sci. 1994 May 31;716:126-38; discussion 138-43., 1994-05-31 [PubMed]
Sentences
No. Mutations Sentence Comment
65 ABCB1 p.Pro866Ala
X
ABCB1 p.Pro866Ala 7912913:65:378
status: NEW
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ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 7912913:65:125
status: NEW
view ABCB1 p.Gly185Val details
ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 7912913:65:183
status: NEW
view ABCB1 p.Gly185Val details
ABCB1 p.Asn183Ser
X
ABCB1 p.Asn183Ser 7912913:65:196
status: NEW
view ABCB1 p.Asn183Ser details
ABCB1 p.Pro223Ala
X
ABCB1 p.Pro223Ala 7912913:65:252
status: NEW
view ABCB1 p.Pro223Ala details
 Summaryofthe PhenotypeoftheVarionsMutations Shown in FIGURE 3 with Respect to Several MDR Drugs Mutation Phenotype Reference Gly 185Val Col t, VP-16t, Vbl J, Act-D J Choi etd.,198935 Gly 185 Val, Asn 183 Ser Col t, Vbl -, Act-D - Currier et d.,19924'3 Pro 223 Ala Col J, Vbl +,Act-D .1 Loo and Clarke, 19934' Gly 338 Ala, Ala 339 Pro Col J, Vbl J, Act-D + Devine et al., 199242 Pro 866 Ala Col J, Vbl 4, Act-D J Loo and Clarke, 199341 Ser 941 Phe Col J, Vbl +,Dox J Gros et d.,199143 FIGURE4. Login to comment