ABCB1 p.Phe104Val
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PMID: 24051054
[PubMed]
Morio F et al: "Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1, MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans."
No.
Sentence
Comment
122
Table 4 Amino acid substitutions in the transcription factors Tac1p, Mrr1p, Upc2p and in Erg11p.a Isolate Amino acid substitutions in Erg11pb Amino acid substitutions in Tac1p Amino acid substitutions in Mrr1pc Amino acid substitutions in Upc2p CAAL28 S405F L47K, F104V, S199N, R206H, V207A, S264P, N396S, D776N, E829Q, N896S, S941P L248Vh ,V341Eh , E1020Q I142Sh , A451Vh CAAL37 E266D, G464S, V456Ih , V488I L47K, S199N, R206H, V207A, D776N, E829Q, E841G, N896S, S941P N937K, E1020Q, F1032L R68Kh , I142Sh , S190Nh , S228Nh CAAL61 G307S, Y447H L47K, K87Nh , M170Ih , N174Dh , F189Sh , S199Nh , R206Hh , V207Ah , A377Vh , N396Sh , N772Kh , D776Nh , E829Qh , S941Ph K884E I142S, G648S CAAL67 G450E L47K, K87Nh , F104Vh , M170Ih , N174Dh , F189Sh , S199N, R206H, V207A, T225Ah , N396S, W442stoph , I558Vh , N772Kh , D776N, E829Q, N896Sh , S941P N937K, E1020Q, F1032L, S1037L I142Sh CAAL74 Y132F, E266D, G448V, V488I L47K, F104Vh , S199Nh , R206Hh , V207Ah , N396Sh , D776Nh , E829Qh , N896Sh , S941Ph S171P, R557K, E1020Q R68Kh , I142S, S228Nh , T273Ah , G648Sh , K684Eh CAAL75 D116E, Y132H, K143R L47K, F104V, S199N, R206H, V207A, N396S, W486C, D776N, E829Q, N896S, S941P, G980Wh S171P, E1020Q R68K h , I142S h , S228N h , T273A h h , heterozygous (mutation in a single allele).
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ABCB1 p.Phe104Val 24051054:122:264
status: NEWX
ABCB1 p.Phe104Val 24051054:122:1102
status: NEW
PMID: 25748216
[PubMed]
Liu JY et al: "Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China."
No.
Sentence
Comment
158
S199N, F104V and L935S were found in both azole-susceptible and -resistant strains.
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ABCB1 p.Phe104Val 25748216:158:7
status: NEW182 Two other known mutations F104V and S199N and one novel mutation, L935S, were observed in some azole-sensitive isolates from our laboratory, suggesting that these substitutions are not involved in azole resistance.
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ABCB1 p.Phe104Val 25748216:182:26
status: NEW