ABCMdb

PMID: 24051054

Morio F, Pagniez F, Besse M, Gay-andrieu F, Miegeville M, Le Pape P
Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1, MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans.
Int J Antimicrob Agents. 2013 Nov;42(5):410-5. doi: 10.1016/j.ijantimicag.2013.07.013. Epub 2013 Aug 29., [PubMed]

Sentences

No. Mutations Sentence Comment

122 ABCB1 p.Phe104Val ABCB1 p.Phe104Val ABCB1 p.Asn396Ser ABCB1 p.Asn396Ser ABCB1 p.Asn396Ser ABCB1 p.Ser228Asn Table 4 Amino acid substitutions in the transcription factors Tac1p, Mrr1p, Upc2p and in Erg11p.a Isolate Amino acid substitutions in Erg11pb Amino acid substitutions in Tac1p Amino acid substitutions in Mrr1pc Amino acid substitutions in Upc2p CAAL28 S405F L47K, F104V, S199N, R206H, V207A, S264P, N396S, D776N, E829Q, N896S, S941P L248Vh ,V341Eh , E1020Q I142Sh , A451Vh CAAL37 E266D, G464S, V456Ih , V488I L47K, S199N, R206H, V207A, D776N, E829Q, E841G, N896S, S941P N937K, E1020Q, F1032L R68Kh , I142Sh , S190Nh , S228Nh CAAL61 G307S, Y447H L47K, K87Nh , M170Ih , N174Dh , F189Sh , S199Nh , R206Hh , V207Ah , A377Vh , N396Sh , N772Kh , D776Nh , E829Qh , S941Ph K884E I142S, G648S CAAL67 G450E L47K, K87Nh , F104Vh , M170Ih , N174Dh , F189Sh , S199N, R206H, V207A, T225Ah , N396S, W442stoph , I558Vh , N772Kh , D776N, E829Q, N896Sh , S941P N937K, E1020Q, F1032L, S1037L I142Sh CAAL74 Y132F, E266D, G448V, V488I L47K, F104Vh , S199Nh , R206Hh , V207Ah , N396Sh , D776Nh , E829Qh , N896Sh , S941Ph S171P, R557K, E1020Q R68Kh , I142S, S228Nh , T273Ah , G648Sh , K684Eh CAAL75 D116E, Y132H, K143R L47K, F104V, S199N, R206H, V207A, N396S, W486C, D776N, E829Q, N896S, S941P, G980Wh S171P, E1020Q R68K h , I142S h , S228N h , T273A h h , heterozygous (mutation in a single allele). Login to comment