PMID: 25748216

Liu JY, Shi C, Wang Y, Li WJ, Zhao Y, Xiang MJ
Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China.
Res Microbiol. 2015 Apr;166(3):153-61. doi: 10.1016/j.resmic.2015.02.009. Epub 2015 Mar 6., [PubMed]
Sentences
No. Mutations Sentence Comment
103 ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:296
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:438
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:561
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:709
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:986
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:1135
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:1216
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:1348
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:1447
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:1608
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:1732
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:1890
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:2174
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:2458
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:2655
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:2745
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:2829
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:2933
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:3130
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:3202
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:3337
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Val437Ile
X
ABCB1 p.Val437Ile 25748216:103:3421
status: NEW
view ABCB1 p.Val437Ile details
ABCB1 p.Thr769Cys
X
ABCB1 p.Thr769Cys 25748216:103:325
status: NEW
view ABCB1 p.Thr769Cys details
ABCB1 p.Thr769Cys
X
ABCB1 p.Thr769Cys 25748216:103:467
status: NEW
view ABCB1 p.Thr769Cys details
ABCB1 p.Thr769Cys
X
ABCB1 p.Thr769Cys 25748216:103:1022
status: NEW
view ABCB1 p.Thr769Cys details
ABCB1 p.Thr769Cys
X
ABCB1 p.Thr769Cys 25748216:103:2064
status: NEW
view ABCB1 p.Thr769Cys details
ABCB1 p.Thr769Cys
X
ABCB1 p.Thr769Cys 25748216:103:2339
status: NEW
view ABCB1 p.Thr769Cys details
of strainsa Site of isolation FLC ITRA VRC Amino acid substitution(s) in Tac1b Missense mutation in TAC1 gene Amino acid substitution(s) in Erg11b Missense mutation in ERG11 gene Gene overexpression Y141 Vagina 16(SDD) >16(R) 0.5(S) S199N, A736V, L935S G596A, C2207T, T2804C A114S, Y205E, Y257H, V437I G340T, T613G or C615A, T769C, G1309A CDR2 Y201 Vagina 16(SDD) 16(R) 1(S) F104V, A736V, L935S T310G, C2207T, T2804C A114S, Y205E, Y257H, V437I G340T, T613G or C615A, T769C, G1309A CDR1 Y205 Vagina 16(SDD) 0.5(SDD) 2(I) D776N, L935S G2326A, T2804C Y132H, Y205E,V437I, G448E T394C, T613G or C615A, G1309A, G1343A CDR1,CDR2 Y206 Vagina 16(SDD) 16(R) 2(I) S199N, D776N, L935S G596A, G2326A, T2804C Y132H, Y205E, V437I, G472R T394C, T613G or C615A, G1309A, G1414A CDR2 Y208 Vagina 32(SDD) 16(R) 1(S) e e Y132H, Y205E, N435V, G448E,D502E T394C, T613G or C615A, A1303G, G1343A, C1506A e Y210 Vagina 16(SDD) 0.25(SDD) 4(R) S199N, N772K, N896S G596A, T2316A, A2687G Y132H, Y205E, Y257H, E260V, V437I, G448E T394C, T613G or C615A, T769C, A779T, G1309A, G1343A CDR1,CDR2 Y203 Vagina 0.5(S) 0.0313(S) <0.0313(S) S199N, L935S G596A, T2804C Y205E, V437I T613G or C615A, G1309A e J026 Sputum 0.5(S) 0.0313(S) 0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e J509 Vagina 32(SDD) 0.25(SDD) 0.25(S) S199N, D776N, L935S G596A, G2326A, T2804C D116E, K128T, Y205E, V437I T348A, A383C, T613G or C615A, G1309A CDR2 J774 Sputum 0.5(S) 0.0313(S) <0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e J5039 Sputum 2(S) 0.0313(S) <0.0313(S) F104V, L935S T310G, T2804C D116E T348A e J5043 Sputum 2(S) 0.0313(S) <0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e H24308 Skin 32(SDD) 0.5(SDD) 0.25(S) S199N, D776N G596A, G2326A, D116E, K128T, K143R, Y205E, V437I T348A, A383C, A428G, T613G or C615A, G1309A CDR2 H75045 Vagina 16(SDD) 0.25(SDD) 2(I) S199N, L935S, F964Y G596A, T2804C, A2890G or A2891T Y132H, Y205E, V437I, G448E T394C, T613G or C 615A, G1309A, G1343A CDR1,CDR2,ERG11 H13139 Skin >64(R) >16(R) 8(R) e e D116E, Y132F, K143Q, Y205E, Y257H T348A, A395T, A427C, T613G or C615A, T769C e H21897 Skin >64(R) >16(R) 16(R) S199N, N772K, N896S G596A, T2316A, A2687G D116E, Y132F, K143Q, Y205E, V437I T348A, A395T, A427C, T613G or C615A, G1309A CDR1,CDR2 H64110 Skin >64(R) 16(R) 4(R) e e D116E, Y132F, K143Q, Y205E, Y257H T348A, A395T, A427C, T613G or C615A, T769C e H30071 Sputum 4(S) <0.0313(S) 0.0313(S) e e D116E T348A e Rc701 Sputum 0.25(S) 0.0313(S) <0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e RC837 Sputum 0.25(S) 0.0313(S) <0.0313(S) S199N, L935S G596A, T2804C D116E T348A e Rc924 Sputum 0.125(S) <0.0313(S) <0.0313(S) F104V, L935S T310G, T2804C Y205E,E226D,V437I T613G or C615A, A789C, G1309A e Rc289 Throat 0.25(S) 0.0313(S) 0.0313(S) e e Y205E, V437I T613G or C615A, G1309A e Rc273 Sputum 0.25(S) <0.0313(S) 0.0313(S) e e D116E, V437I T348A, G1309A e Rc923 Sputum 0.25(S) 0.0313(S) 0.0313(S) S199N, L935S G596A, T2804C Y205E, A255V, V437I T613G or C615A, C764T, G1309A e Rc592 Sputum 0.25(S) 0.0313(S) <0.0313(S) e e D116E, Y205E T348A, T613G or C615A e Rc271 Stool 0.25(S) <0.0313(S) <0.0313(S) F104V, L935S T310G, T2804C D116E, V437I T348A, G1309A e Rc286 Sputum 0.25(S) 0.0313(S) 0.0313(S) e Y205E, V437I T613G or C615A, G1309A e Rc944 Sputum 1(S) 0.0313(S) 0.0313(S) e D116E T348A e Rc963 Throat 0.25(S) 0.0313(S) 0.0313(S) e Y205E, V437I T613G or C615A, G1309A e Rc827 Sputum 0.125(S) <0.0313(S) <0.0313(S) e Y205E, V437I T613G or C615A, G1309A e a Y, Shanghai First Maternity and Infant Hospital at Tonji University School of Medicine. Login to comment
158 ABCB1 p.Phe104Val
X
ABCB1 p.Phe104Val 25748216:158:7
status: NEW
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S199N, F104V and L935S were found in both azole-susceptible and -resistant strains. Login to comment
182 ABCB1 p.Phe104Val
X
ABCB1 p.Phe104Val 25748216:182:26
status: NEW
view ABCB1 p.Phe104Val details
Two other known mutations F104V and S199N and one novel mutation, L935S, were observed in some azole-sensitive isolates from our laboratory, suggesting that these substitutions are not involved in azole resistance. Login to comment