ABCC4 p.Tyr477Trp
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PMID: 16412422
[PubMed]
Ambudkar SV et al: "The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding."
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77
For example, the substitution of Y401 with W resulted in an increase in the Km (ATP) during ATP hydrolysis and an increase in the Kd (TNPATP) in a binding assay using the fluorescent analog of ATP, TNPATP.1 Similar results were also reported for the Y477W mutant of bacterial HlyB-NBD [29].
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ABCC4 p.Tyr477Trp 16412422:77:250
status: NEW