PMID: 16412422

Ambudkar SV, Kim IW, Xia D, Sauna ZE
The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.
FEBS Lett. 2006 Feb 13;580(4):1049-55. Epub 2005 Dec 22., [PubMed]
Sentences
No. Mutations Sentence Comment
77 ABCC4 p.Tyr477Trp
X
ABCC4 p.Tyr477Trp 16412422:77:250
status: NEW
view ABCC4 p.Tyr477Trp details
 For example, the substitution of Y401 with W resulted in an increase in the Km (ATP) during ATP hydrolysis and an increase in the Kd (TNPATP) in a binding assay using the fluorescent analog of ATP, TNPATP.1 Similar results were also reported for the Y477W mutant of bacterial HlyB-NBD [29]. Login to comment