ABCMdb

ABCC1 p.Ser1034Cys

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Publications

PMID: 19307369 [PubMed] Parquet V et al: "Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria."

No. Sentence Comment

99 The following mutations were identified in at least one strain: Pfcrt M74I, N75E, K76T, A220S, Q271(E/V), N326S, I356T, and I371R; Pfmrp H191Y and S437A; and Pfmdr1 N86Y, Y184F, S1034C, N1042D, and D1246Y (Table 2). Login to comment

PMID: 10704942 [PubMed] Abrahem A et al: "Pleiotropic resistance to diverse antimalarials in actinomycin D-resistant Plasmodium falciparum."

No. Sentence Comment

185 Although these results point to the lack of involvement of Pfmdr1 in actD resistance, earlier reports have suggested that several point mutations in Pfmdr1 (Asn86Tyr, Ser1034Cys, Asn1042Asp, and Asp1246Tyr) may be important to chloroquine or mefloquine resistance [38]. Login to comment

PMID: 8790436 [PubMed] Ruetz S et al: "The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells."

No. Sentence Comment

38 Mutant variants ofpftndrl bearing a single Ser -> Cys substitution at position 1034 (S1034C, clone M1034), a single Asn -> Asp substitution at position 1042 (N1042D, clone M1042), or both mutations (S1034C/N1042D; clone DM) were generated by site-directed mutagenesis (26). Login to comment
88 The expression of the wild-type P. falciparum Pgh-1 protein (A) and mutant variants bearing single S1034C (B) or N1042D (C) mutations or both (D) in permeabilized yeast S. cerevisiae spheroplasts is shown by immunofluorescence using a specific antiserum (rabbit anti-Pgh-1) at a 1:100 dilution, followed by an fluorescein isothiocyanate-coupled goat anti-rabbit antibody at a dilution of 1:800. Login to comment
94 Time-dependent cell growth in absence (solid symbols) or presence (open symbols) of MFQ at 150 ,ug/ml was established for JPY201 transformants expressing wild-type Pgh-1, wild-type Mdr3 (Mdr3S), or Pgh-1 variants bearing single S1034C (M1034) or single N1042D (M1042) mutations or both mutations (S1034C/N1042D; DM) in predicted TM11 or a mutant variant of Mdr3 (S939F; Mdr3F). Login to comment
97 JPY201 cells expressing wild-type Pgh-1, wild-type Mdr3 (Mdr3S), or mutant Pgh-1 variants bearing single S1034C (M1034), single N1042D M1042) mutations, or both mutations (S1034C/N1042D; DM) were evaluated for growth in increasing concentrations of MFQ. Login to comment
133 JPY201 cells expressing either wild-type Pgh-1 or a double mutant Pgh-1 variant (S1034C/ N1042D; DM) were incubated with QA. Login to comment