ABCC4 p.Met184Val
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PMID: 19470503
[PubMed]
Wang X et al: "Retention of metabolites of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel anti-human immunodeficiency virus type 1 thymidine analog, in cells."
No.
Sentence
Comment
23
Moreover, 4Ј-Ed4T was found to be active against multidrug-resistant HIV-1 clinical isolates, while a unique pattern of RT resistance mutations (P119S, T165A, and M184V) in the virus was observed under the selection pressure of 4Ј-Ed4T in vitro (13).
X
ABCC4 p.Met184Val 19470503:23:169
status: NEW
PMID: 19001108
[PubMed]
Cihlar T et al: "Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation."
No.
Sentence
Comment
24
Importantly, the parent nucleotide GS-9148 shows a favorable resistance profile and retains its activity against a wide range of nucleoside-resistant HIV-1 variants, including viruses with multiple M184V, K65R, L74V, and thymidine analog mutations in reverse transcriptase (5).
X
ABCC4 p.Met184Val 19001108:24:198
status: NEW