PMID: 19001108

Cihlar T, Laflamme G, Fisher R, Carey AC, Vela JE, Mackman R, Ray AS
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.
Antimicrob Agents Chemother. 2009 Jan;53(1):150-6. Epub 2008 Nov 10., [PubMed]
Sentences
No. Mutations Sentence Comment
24 ABCC4 p.Met184Val
X
ABCC4 p.Met184Val 19001108:24:198
status: NEW
view ABCC4 p.Met184Val details
 Importantly, the parent nucleotide GS-9148 shows a favorable resistance profile and retains its activity against a wide range of nucleoside-resistant HIV-1 variants, including viruses with multiple M184V, K65R, L74V, and thymidine analog mutations in reverse transcriptase (5). Login to comment