ABCB1 p.Arg659Gln
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PMID: 15897556
[PubMed]
Yang T et al: "A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing."
No.
Sentence
Comment
220
In fact, in a previous study (19), no cell surface HLA was detectable in a small cell lung cancer cell line due to selective expression of another TAP-1 variant, R659Q, which was later shown to have as much as 50% of wild-type transporter activity (34).
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ABCB1 p.Arg659Gln 15897556:220:162
status: NEW217 In fact, in a previous study (19), no cell surface HLA was detectable in a small cell lung cancer cell line due to selective expression of another TAP-1 variant, R659Q, which was later shown to have as much as 50% of wild-type transporter activity (34).
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ABCB1 p.Arg659Gln 15897556:217:162
status: NEW
PMID: 10581370
[PubMed]
Abele R et al: "Function of the transport complex TAP in cellular immune recognition."
No.
Sentence
Comment
386
In addition, both NBDs are essential for TAP function because mutation of one NBD (R659Q of hTAP1) leads to a loss of transport function [90].
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ABCB1 p.Arg659Gln 10581370:386:83
status: NEW501 Another interesting example of a tumor escape mechanism was found in small lung cancer where a TAP1 (R659Q) mutant was identi'ed [90].
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ABCB1 p.Arg659Gln 10581370:501:101
status: NEW