PMID: 10581370

Abele R, Tampe R
Function of the transport complex TAP in cellular immune recognition.
Biochim Biophys Acta. 1999 Dec 6;1461(2):405-19., [PubMed]
Sentences
No. Mutations Sentence Comment
352 ABCB3 p.Ala374Asp
X
ABCB3 p.Ala374Asp 10581370:352:97
status: NEW
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 Moreover, two pairs of residues (217/218) and (374/ 380) of rat TAP and a single point mutation (A374D) of human TAP a¡ect the substrate speci'city [78,80]. Login to comment 386 ABCB1 p.Arg659Gln
X
ABCB1 p.Arg659Gln 10581370:386:83
status: NEW
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 In addition, both NBDs are essential for TAP function because mutation of one NBD (R659Q of hTAP1) leads to a loss of transport function [90]. Login to comment 501 ABCB1 p.Arg659Gln
X
ABCB1 p.Arg659Gln 10581370:501:101
status: NEW
view ABCB1 p.Arg659Gln details
 Another interesting example of a tumor escape mechanism was found in small lung cancer where a TAP1 (R659Q) mutant was identi'ed [90]. Login to comment