ABCA1 p.Gln71Leu
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PMID: 15147902
[PubMed]
Engel T et al: "ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export."
No.
Sentence
Comment
106
ARL7(G2A) lacks a myristoylation site, ARL(T27N) represents the inactive GDP-bound (dominant negative) and ARL7(Q71L) the active GTP-bound state (dominant active).
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ABCA1 p.Gln71Leu 15147902:106:112
status: NEW121 Conversely, the Q71L mutant resulted in a very similar staining pattern and affected the cellular morphology the same way as wt ARL7 with less filopodia (Fig. 4D).
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ABCA1 p.Gln71Leu 15147902:121:16
status: NEW137 (A) ARL7(wt), (B) ARL7(G2A), (C) ARL7(T27N), (D) ARL7(Q71L).
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ABCA1 p.Gln71Leu 15147902:137:54
status: NEW163 Over-expression of the two ARL7 forms (ARL7-EGFP and ARL7(Q71L)-EGFP) which stimulated cholesterol efflux were associated with quite extensive alterations of cell morphology.
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ABCA1 p.Gln71Leu 15147902:163:58
status: NEW165 We presume that some of these changes may have been due to accumulation of ARL7-EGFP and ARL7(Q71L)-EGFP at the terminus of their transport route, presumably as a consequence of a very slow return to their starting point.
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ABCA1 p.Gln71Leu 15147902:165:94
status: NEW
PMID: 23220274
[PubMed]
Lin S et al: "BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function."
No.
Sentence
Comment
83
Cells overexpressing ARF1-Q71L, which is assumed to be constitutively active with GTP-bound, or WT-ARF1, showed increased surface ABCA1.
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ABCA1 p.Gln71Leu 23220274:83:26
status: NEW84 In addition, ARF-Q71L stimulated a much greater surface distribution of ABCA1 than ARF1-WT.
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ABCA1 p.Gln71Leu 23220274:84:17
status: NEW88 An increased cholesterol content was found in cells overexpressing Arf1-WT and Arf1-Q71L (Figure 5C).
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ABCA1 p.Gln71Leu 23220274:88:84
status: NEW