PMID: 23220274

Lin S, Zhou C, Neufeld E, Wang YH, Xu SW, Lu L, Wang Y, Liu ZP, Li D, Li C, Chen S, Le K, Huang H, Liu P, Moss J, Vaughan M, Shen X
BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function.
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):e31-8. doi: 10.1161/ATVBAHA.112.300720. Epub 2012 Dec 6., [PubMed]
Sentences
No. Mutations Sentence Comment
83 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 23220274:83:26
status: NEW
view ABCA1 p.Gln71Leu details
 Cells overexpressing ARF1-Q71L, which is assumed to be constitutively active with GTP-bound, or WT-ARF1, showed increased surface ABCA1. Login to comment 84 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 23220274:84:17
status: NEW
view ABCA1 p.Gln71Leu details
 In addition, ARF-Q71L stimulated a much greater surface distribution of ABCA1 than ARF1-WT. Login to comment 88 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 23220274:88:84
status: NEW
view ABCA1 p.Gln71Leu details
 An increased cholesterol content was found in cells overexpressing Arf1-WT and Arf1-Q71L (Figure 5C). Login to comment