PMID: 15147902

Engel T, Lueken A, Bode G, Hobohm U, Lorkowski S, Schlueter B, Rust S, Cullen P, Pech M, Assmann G, Seedorf U
ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export.
FEBS Lett. 2004 May 21;566(1-3):241-6., [PubMed]
Sentences
No. Mutations Sentence Comment
106 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 15147902:106:112
status: NEW
view ABCA1 p.Gln71Leu details
 ARL7(G2A) lacks a myristoylation site, ARL(T27N) represents the inactive GDP-bound (dominant negative) and ARL7(Q71L) the active GTP-bound state (dominant active). Login to comment 121 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 15147902:121:16
status: NEW
view ABCA1 p.Gln71Leu details
 Conversely, the Q71L mutant resulted in a very similar staining pattern and affected the cellular morphology the same way as wt ARL7 with less filopodia (Fig. 4D). Login to comment 137 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 15147902:137:54
status: NEW
view ABCA1 p.Gln71Leu details
 (A) ARL7(wt), (B) ARL7(G2A), (C) ARL7(T27N), (D) ARL7(Q71L). Login to comment 163 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 15147902:163:58
status: NEW
view ABCA1 p.Gln71Leu details
 Over-expression of the two ARL7 forms (ARL7-EGFP and ARL7(Q71L)-EGFP) which stimulated cholesterol efflux were associated with quite extensive alterations of cell morphology. Login to comment 165 ABCA1 p.Gln71Leu
X
ABCA1 p.Gln71Leu 15147902:165:94
status: NEW
view ABCA1 p.Gln71Leu details
 We presume that some of these changes may have been due to accumulation of ARL7-EGFP and ARL7(Q71L)-EGFP at the terminus of their transport route, presumably as a consequence of a very slow return to their starting point. Login to comment