ABCA1 p.Met671Leu
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PMID: 22119192
[PubMed]
Kim J et al: "MiR-106b impairs cholesterol efflux and increases Abeta levels by repressing ABCA1 expression."
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41
pcDNA3.1- mouse ABCA1 open reading frame (ORF) without 3' untranslated region (UTR) and pAG3-Swedish mutant (K670N/M671L) APPsw ORF without 3' UTR were kind gifts from Dr. David M. Holtzman (Washington University, St. Louis, USA) and Dr. Todd Golde (University of Florida, Gainesville, USA), respectively.
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ABCA1 p.Met671Leu 22119192:41:115
status: NEW70 Measurement of secreted Aβ levels Neuro2a cells were plated at a density of 1.25×105 cells/well in a 24-well plate 1 day before transfection. Neuro2A cells were first transfected with 0.3 μg of pAG3-Swedish mutant (K670N/M671L) APPsw ORF without 3' UTR for 8 h and allowed to recover overnight. Then, miR-106b or a scrambled negative control was transfected into cells.
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ABCA1 p.Met671Leu 22119192:70:235
status: NEW
PMID: 19570031
[PubMed]
Lefterov I et al: "Memory deficits in APP23/Abca1+/- mice correlate with the level of Abeta oligomers."
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33
APP23 transgenic mice express the human familial AD mutant APP751 with Swedish double mutations at positions 670/671 (APPK670N, M671L) (Sturchler-Pierrat et al., 1997).
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ABCA1 p.Met671Leu 19570031:33:128
status: NEW32 APP23 transgenic mice express the human familial AD mutant APP751 with Swedish double mutations at positions 670/671 (APPK670N, M671L) (Sturchler-Pierrat et al., 1997).
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ABCA1 p.Met671Leu 19570031:32:128
status: NEW
PMID: 16207713
[PubMed]
Koldamova R et al: "Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice."
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27
We used APP23 transgenic mice expressing human familial AD mutant APP751 with Swedish double mutation at positions 670/671 (APPK670N, M671L) (23).
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ABCA1 p.Met671Leu 16207713:27:134
status: NEW