PMID: 16207713

Koldamova R, Staufenbiel M, Lefterov I
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
J Biol Chem. 2005 Dec 30;280(52):43224-35. Epub 2005 Oct 5., [PubMed]
Sentences
No. Mutations Sentence Comment
27 ABCA1 p.Met671Leu
X
ABCA1 p.Met671Leu 16207713:27:134
status: NEW
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 We used APP23 transgenic mice expressing human familial AD mutant APP751 with Swedish double mutation at positions 670/671 (APPK670N, M671L) (23). Login to comment 229 ABCA1 p.Arg219Lys
X
ABCA1 p.Arg219Lys 16207713:229:35
status: NEW
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 Wollmer et al. (20) found that the R219K variant of ABCA1, associated with increased HDL-cholesterol levels and a decreased risk of atherosclerosis (43), delayed the age of onset of LOAD. Login to comment 233 ABCA1 p.Arg219Lys
X
ABCA1 p.Arg219Lys 16207713:233:35
status: NEW
view ABCA1 p.Arg219Lys details
 Wollmer et al. (20) found that the R219K variant of ABCA1, associated with increased HDL-cholesterol levels and a decreased risk of atherosclerosis (43), delayed the age of onset of LOAD. Login to comment