ABCC8 p.Leu1014Ser
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PMID: 21651761
[PubMed]
Antonio-Nkondjio C et al: "Anopheles gambiae distribution and insecticide resistance in the cities of Douala and Yaounde (Cameroon): influence of urban agriculture and pollution."
No.
Sentence
Comment
79
To screen for the presence of the kdr alleles (L1014F and L1014S) conferring resistance to DDT and pyrethroids, DNA extracted from individuals exposed to insecticide was tested using the Hot Ligation Oligonucleotide Assay (HOLA) of Lynd et al [26] and the TaqMan assay [27].
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ABCC8 p.Leu1014Ser 21651761:79:58
status: NEW152 Only one specimen in Douala was found with the L1014S allele.
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ABCC8 p.Leu1014Ser 21651761:152:47
status: NEW197 gambiae molecular forms Genotypes Kdrw/Kdrw Kdrw/KdrE Kdrw/S S/S Total F(Kdr) P(HW) Douala M form 228 1 170 62 460 0.68 P = 0.002 S form - - 1 - 1 Yaoundé M form 79 0 124 115 318 0.44 P = 0.0003 S form - - 2 - 2 Total 307 1 296 177 781 S, wild type; Kdrw, L1014F substitution « West Africa"; KdrE, L1014S substitution "East Africa", Kdrw/S, heterozygote; P(HW), goodness of fit to Hardy Weinberg Equilibrium (significant if P < 0.05).
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ABCC8 p.Leu1014Ser 21651761:197:308
status: NEW
PMID: 22384107
[PubMed]
Ndiath MO et al: "Resistance to DDT and pyrethroids and increased kdr mutation frequency in An. gambiae after the implementation of permethrin-treated nets in Senegal."
No.
Sentence
Comment
5
Species and molecular forms as well as the presence of L1014F and L1014S kdr mutations were assessed by PCR.
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ABCC8 p.Leu1014Ser 22384107:5:66
status: NEW7 Findings: No specimen studied presented the L1014S mutation.
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ABCC8 p.Leu1014Ser 22384107:7:44
status: NEW80 Molecular identification and kdr genotyping In the subsample of mosquitoes used for bioassay and in adults sampled by HLC during the longitudinal study, detection of L1014F and L1014S kdr mutations (thereafter identified as kdr-w and kdr-e respectively) was performed by PCR [27,28].
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ABCC8 p.Leu1014Ser 22384107:80:177
status: NEW91 gambiae s.l. From July 2006 to December 2010, no specimen with L1014S (kdr-e) mutation was identified.
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ABCC8 p.Leu1014Ser 22384107:91:63
status: NEW314 Djegbe I, Boussari O, Sidick A, Martin T, Ranson H, et al. (2011) Dynamics of insecticide resistance in malaria vectors in Benin: first evidence of the presence of L1014S kdr mutation in Anopheles gambiae from West Africa.
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ABCC8 p.Leu1014Ser 22384107:314:164
status: NEW