ABCC8 p.Leu266Met
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PMID: 12626391
[PubMed]
Heissigerova H et al: "Molecular modeling of glycosyltransferases involved in the biosynthesis of blood group A, blood group B, Forssman, and iGb3 antigens and their interaction with substrates."
No.
Sentence
Comment
154
Comparison with biochemical data on GTA and GTB The differences in amino acids between GTA and GTB are limited to four residues: Arg176Gly, Gly235Ser, Leu266Met, and Gly268Ala (Yamamoto et al., 1990).
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ABCC8 p.Leu266Met 12626391:154:151
status: NEW156 As discussed, Leu266Met and Gly268Ala substitutions (region LBR-E) have a crucial effect on the shape of the nucleotide binding pocket and directly affect the specificity for the nucleotide sugar.
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ABCC8 p.Leu266Met 12626391:156:14
status: NEW
PMID: 10362841
[PubMed]
Imberty A et al: "Fold recognition study of alpha3-galactosyltransferase and molecular modeling of the nucleotide sugar-binding domain."
No.
Sentence
Comment
53
Only four amino acids differ between bgA and bgB, i.e., Arg176Gly, Gly235Ser, Leu266Met,andGly268Ala(Yamamotoetal.,1990),thetwolast ones being the more crucial in determining nucleotide-sugar specificity (Yamamoto and Hakamori, 1990; Seto et al., 1997).
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ABCC8 p.Leu266Met 10362841:53:78
status: NEW152 One intriguing question is why do the Leu266Met and Gly268Ala mutations alter the specificity from blood group A to blood group B, i.e., from a GalNAc to a Gal-transferase.
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ABCC8 p.Leu266Met 10362841:152:38
status: NEW