ABCMdb

PMID: 10362841

Imberty A, Monier C, Bettler E, Morera S, Freemont P, Sippl M, Flockner H, Ruger W, Breton C
Fold recognition study of alpha3-galactosyltransferase and molecular modeling of the nucleotide sugar-binding domain.
Glycobiology. 1999 Jul;9(7):713-22., [PubMed]

Sentences

No. Mutations Sentence Comment

53 ABCC8 p.Leu266Met Only four amino acids differ between bgA and bgB, i.e., Arg176Gly, Gly235Ser, Leu266Met,andGly268Ala(Yamamotoetal.,1990),thetwolast ones being the more crucial in determining nucleotide-sugar specificity (Yamamoto and Hakamori, 1990; Seto et al., 1997). Login to comment 152 ABCC8 p.Leu266Met One intriguing question is why do the Leu266Met and Gly268Ala mutations alter the specificity from blood group A to blood group B, i.e., from a GalNAc to a Gal-transferase. Login to comment