PMID: 12626391

Heissigerova H, Breton C, Moravcova J, Imberty A
Molecular modeling of glycosyltransferases involved in the biosynthesis of blood group A, blood group B, Forssman, and iGb3 antigens and their interaction with substrates.
Glycobiology. 2003 May;13(5):377-86. Epub 2003 Jan 22., [PubMed]
Sentences
No. Mutations Sentence Comment
154 ABCC8 p.Leu266Met
X
ABCC8 p.Leu266Met 12626391:154:151
status: NEW
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 Comparison with biochemical data on GTA and GTB The differences in amino acids between GTA and GTB are limited to four residues: Arg176Gly, Gly235Ser, Leu266Met, and Gly268Ala (Yamamoto et al., 1990). Login to comment 156 ABCC8 p.Leu266Met
X
ABCC8 p.Leu266Met 12626391:156:14
status: NEW
view ABCC8 p.Leu266Met details
 As discussed, Leu266Met and Gly268Ala substitutions (region LBR-E) have a crucial effect on the shape of the nucleotide binding pocket and directly affect the specificity for the nucleotide sugar. Login to comment