ABCMdb

ABCB1 p.Ala220Ser

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Publications

PMID: 16535862 [PubMed] Pradines B et al: "Chemosensitizers in drug transport mechanisms involved in protozoan resistance."

No. Sentence Comment

381 Five mutations in PfCRT, resulting in the amino acid change K76T, M74I, N75E, A220S and R371I, are systematically identified in resistance-reversed Asian, African and Brazilian parasites, which possess the CVIET haplotype [247]. Login to comment

PMID: 18385361 [PubMed] Zakeri S et al: "Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparum."

No. Sentence Comment

60 Following amplification of the fragments concerned, polymorphisms in the pfcrt and pfmdr1 genes were assessed by the mutation-specific restriction endonuclease digestion to detect single nucleotide polymorphisms (SNPs) in pfcrt at positions K76T, A220S, Q271E, N326S/D, I356T/L, and R371I/T and in pfmdr1 at positions N86Y/H, Y184F, S1034C, N1042D, and D1246Y.45,46 A number of restriction enzymes were used for RFLP of PCR products.45,46 For pfcrt, the PCR products were digested with ApoI, BglI, XmnI, MseI, CaiI, and AFlII to determine the polymorphisms at codons 76, 220, 271, 326, 356, and 371, respectively (detailed information is available on the internet at http://medschool.umaryland.edu/cvd/ nejm2001djimde.asp). Login to comment
88 Sequence analyses of codons N326S/D TABLE 1 Distribution of pfcrt polymorphisms in pre-and post-treatment samples from Iran based on PCR/RFLP* Pfcrt K76T A220S Q271E N326S/D I356T/L R371I/T Total (%) Pre-treatment K A Q N I/L R 4 (2.3%) T A Q S/D I/L R 1 (0.6%) T S Q S/D I/L R 170 (97.1%) T = 97.7% S = 97% E = 0 S/D = 97.7% I/L = 100% I/T = 0 175 (100) Post-treatment K A Q N I/L R - T A Q S/D I/L R 1 (4%) T S Q S/D I/L R 24 (96%) T = 100% S = 96% E = 0 S/D = 100% I/L = 100% I/T = 0 25 (100%) * Analysis of codon N326S/D by MseI restriction enzyme digestion showed that 97.7% of our samples had either amino acid serine (S) or aspartic acid (D). Login to comment

PMID: 19307369 [PubMed] Parquet V et al: "Atorvastatin is a promising partner for antimalarial drugs in treatment of Plasmodium falciparum malaria."

No. Sentence Comment

99 The following mutations were identified in at least one strain: Pfcrt M74I, N75E, K76T, A220S, Q271(E/V), N326S, I356T, and I371R; Pfmrp H191Y and S437A; and Pfmdr1 N86Y, Y184F, S1034C, N1042D, and D1246Y (Table 2). Login to comment

PMID: 20053293 [PubMed] Marfurt J et al: "Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance."

No. Sentence Comment

67 Assessment of SNPs for drug resistant malaria was done for pfmdr1 mutations N86Y, Y184F, S1034C, N1042D and D1246Y, pfcrt mutations K76T, H97Q, T152A, S163R, A220S, Q271E, N326D/S, I356L/T and R371I, pfdhfr mutations A16V, N51I, C59R, S108N/T and I164L, pfdhps mutations S436A, A437G, K540E, A581G and A613T/S, and pfATPase6 mutations S538R, Q574P, A623E, N683K and S769N. Login to comment
94 Polymorphisms were found in pfmdr1 SNPs N86Y, Y184F and N1042D, pfcrt SNPs K76T, A220S, N326D, I356L and S163R, pfdhfr SNPs C59R and S108N, and pfdhps SNPs A437G and K540E. Login to comment
99 Frequencies of A220S were highest at the North Coast and lower in Karimui and the Wosera. Login to comment
121 The most obvious changes were related to the allele frequencies of pfcrt N326D, I356L and A220S, which all decreased over time, as did pfdhpsA437G, while the frequencies of the pfdhfr mutants increased (Table S2, Additional file 2). Login to comment

PMID: 11512154 [PubMed] Peel SA et al: "The ABC transporter genes of Plasmodium falciparum and drug resistance."

No. Sentence Comment

35 Sequence analysis of chloroquine resistant parasites from diverse geographic regions (Asia,Africa,SouthAmerica) revealed a polymorphic gene, which in all cases included intra-allelic mutations Lys 76Thr and Ala 220Ser , as well as mutations in two to six additional codons. Login to comment