ABCMdb

PMID: 20053293

Marfurt J, Smith TA, Hastings IM, Muller I, Sie A, Oa O, Baisor M, Reeder JC, Beck HP, Genton B
Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance.
Malar J. 2010 Jan 7;9:8., [PubMed]

Sentences

No. Mutations Sentence Comment

67 ABCB1 p.Ala220Ser Assessment of SNPs for drug resistant malaria was done for pfmdr1 mutations N86Y, Y184F, S1034C, N1042D and D1246Y, pfcrt mutations K76T, H97Q, T152A, S163R, A220S, Q271E, N326D/S, I356L/T and R371I, pfdhfr mutations A16V, N51I, C59R, S108N/T and I164L, pfdhps mutations S436A, A437G, K540E, A581G and A613T/S, and pfATPase6 mutations S538R, Q574P, A623E, N683K and S769N. Login to comment 94 ABCB1 p.Ala220Ser Polymorphisms were found in pfmdr1 SNPs N86Y, Y184F and N1042D, pfcrt SNPs K76T, A220S, N326D, I356L and S163R, pfdhfr SNPs C59R and S108N, and pfdhps SNPs A437G and K540E. Login to comment 99 ABCB1 p.Ala220Ser Frequencies of A220S were highest at the North Coast and lower in Karimui and the Wosera. Login to comment 121 ABCB1 p.Ala220Ser The most obvious changes were related to the allele frequencies of pfcrt N326D, I356L and A220S, which all decreased over time, as did pfdhpsA437G, while the frequencies of the pfdhfr mutants increased (Table S2, Additional file 2). Login to comment