ABCB1 p.Ala595Gly
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PMID: 12019078
[PubMed]
Perea S et al: "Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis."
No.
Sentence
Comment
199
Nucleotide and amino acid substitutions in ERG11 genes from C. dubliniensis clinical isolates Patient no. Isolate FLC MIC (g/ml) Substitutiona S113F V125A F126L F148L T199A R210G D288G G289D L300P G307A R398G V437A G464S P515S 1 3300 1 T374C C378A T1310C 3946 64 C378A A595G A628G 4380 64 G1390A 4713 64 G1390A 4806 64 T442C G920C C1543T 4807 32 A863G T899C T1310C 5143 32 T374C C378A A1192G T1310C 2 3466 0.25 4572 64 C338T G866A a The base numbers are with respect to the first ATG codon of ERG11.
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ABCB1 p.Ala595Gly 12019078:199:277
status: NEW
PMID: 25995342
[PubMed]
Zhu Y et al: "Antiandrogens Inhibit ABCB1 Efflux and ATPase Activity and Reverse Docetaxel Resistance in Advanced Prostate Cancer."
No.
Sentence
Comment
29
b-Tubulin mutations, such as T26A, A595G, and F270I, have been demonstrated to impair tubulin polymerization in the presence of docetaxel in prostate cancer and breast cancer cell lines (13, 14).
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ABCB1 p.Ala595Gly 25995342:29:35
status: NEW